GABRR1
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Official Full Name
gamma-aminobutyric acid (GABA) receptor, rho 1 -
Overview
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. -
Synonyms
GABRR1;gamma-aminobutyric acid (GABA) receptor, rho 1;gamma-aminobutyric acid receptor subunit rho-1;bA135P14.1 (gamma-aminobutyric acid (GABA) receptor rho 1);GABA(A) receptor subunit rho-1;gamma aminobutyric acid receptor rho 1;gamma-aminobutyric acid (GABA) A receptor rho-1;gamma-aminobutyric acid (GABA) receptor rho 1;MGC163216;GABA(C) receptor;OTTHUMP00000016849;OTTHUMP00000209035;gamma-aminobutyric acid (GABA) A receptor, rho-1;bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1)
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Avi
- Fc
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRR1-3165Z | Recombinant Zebrafish GABRR1 | Mammalian Cells | Zebrafish | His |
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| GABRR1-6159M | Recombinant Mouse GABRR1 Protein | Mammalian Cells | Mouse | His |
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| GABRR1-1555H | Recombinant Human GABRR1 Protein, His&GST-tagged | E.coli | Human | GST&His | Thr22-Ile281 |
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| GABRR1-3437M | Recombinant Mouse GABRR1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GABRR1-3437M-B | Recombinant Mouse GABRR1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GABRR1-4651H | Recombinant Human GABRR1 Protein | Wheat Germ | Human | Non |
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| GABRR1-5202HF | Recombinant Full Length Human GABRR1 Protein | In Vitro Cell Free System | Human | Full L. 217 amino acids |
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Involved Pathway
GABRR1 involved in several pathways and played different roles in them. We selected most pathways GABRR1 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PRLHR2A,Gh,RXFP1,HTR1A,MC3R,TAAR7F,CHRNB3,GABBR2,IL12,NMUR1 |
| Nicotine addiction | GRIN2C,GRIA4,GABRD,GRIN2B,SLC17A8,GRIN3B,GABRB2,GABRA6,GABRB1,GABRA5 |
| GABAergic synapse | SLC38A2,GNG12,GNG13,GNG7,GABBR1,PRKACA,GNG5,GABRA6,GNG10,GABBR2 |
| Retrograde endocannabinoid signaling | PLCB1,PRKACG,GNG8,PLCB2,GABRB2,NAPEPLD,GNGT2,GNAQ,GNG11,MAPK10 |
Protein Function
GABRR1 has several biochemical functions, for example, GABA receptor activity,GABA-A receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRR1 itself. We selected most functions GABRR1 had, and list some proteins which have the same functions with GABRR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular ligand-gated ion channel activity | Chrng,GABRR2A,SIX2A,CHRNA10A,GLRBA,GABRP,GABRR3,GABRZ,GABRR3A,CHRNB1L |
| protein domain specific binding | HOXB1,TFDP1,ITGA3,ACSL3,DDX20,NEDD4,PRKCZ,PHRF1,MPP5,ACTN2 |
| protein heterodimerization activity | Pdgfa&Pdgfb,TPD52L2,UNC13A,NEFH,CUL5,UBA2,H2AFJ,HIST1H2AL,HIST1H2BN,EXT1 |
| protein homodimerization activity | HEYL,HOGA1,SLK,GSTM3,GLA,RQCD1,ATPIF1A,CPNE1,ACCS,CAV2 |
| chloride channel activity | CLCC1,GABRG1,CFTR,CLIC3,SLC26A6L,SLC26A3.1,SLC26A4,CLCA1,CLCN4,SLC1A4 |
| GABA-A receptor activity | GABRR3,GABRA6A,GABRR2A,GABRZ,GABRD,GABRE,GABRB2,GABRA1,GABRR2,GABRG2 |
Interacting Protein
GABRR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRR1.
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References
- Santoro, ML; Ota, VK; et al. Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR). SCHIZOPHRENIA RESEARCH 157:163-168(2014).
- Do, DN; Strathe, AB; et al. Genome-Wide Association Study Reveals Genetic Architecture of Eating Behavior in Pigs and Its Implications for Humans Obesity by Comparative Mapping. PLOS ONE 8:-(2013).
