GABRG3
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, gamma 3 -
Overview
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the;mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of;these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors;are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein;encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants;encoding distinct isoforms have been found for this gene. -
Synonyms
GABRG3;gamma-aminobutyric acid (GABA) A receptor, gamma 3;gamma-aminobutyric acid receptor subunit gamma-3;GABA(A) receptor;GABA(A) receptor subunit gamma 3;GABR G3;GABRG 3;Gamma aminobutyric acid (GABA) A receptor gamma 3;Gamma aminobutyric acid A receptor gamma 3;Gamma aminobutyric acid receptor subunit gamma 3;GABA(A) receptor subunit gamma-3
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cells
- HEK293
- His
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRG3-2454R | Recombinant Rat GABRG3 Protein | Mammalian Cells | Rat | His |
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| GABRG3-6156M | Recombinant Mouse GABRG3 Protein | Mammalian Cells | Mouse | His |
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| GABRG3-6056HCL | Recombinant Human GABRG3 293 Cell Lysate | HEK293 | Human | Non |
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| GABRG3-2110R | Recombinant Rat GABRG3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GABRG3-2110R-B | Recombinant Rat GABRG3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GABRG3-3435M | Recombinant Mouse GABRG3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GABRG3-3435M-B | Recombinant Mouse GABRG3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GABRG3 involved in several pathways and played different roles in them. We selected most pathways GABRG3 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nicotine addiction | GABRB2,CHRNA6,GABRE,GRIA3,GRIN2A,GABRA5,GRIA1,GABRR3,GABRA3,GABRA4 |
| Retrograde endocannabinoid signaling | NAPEPLD,GNGT1,PLCB1,GNG4,PRKACA,RIMS1,GNAI3,GNG10,GABRG1,FAAH |
| GABAergic synapse | NSF,SLC12A5,GNB2,GPHN,GNG5,HAP1,PRKCA,GNG8,GNG4,GNGT2 |
| Neuroactive ligand-receptor interaction | AGTR1A,SSTR2,GRM6B,PTGDR,TAAR10C,F2RL1.1,OPRD1B,HRH4,NPBWR2,TACR3L |
Protein Function
GABRG3 has several biochemical functions, for example, contributes_to GABA-A receptor activity,contributes_to benzodiazepine receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRG3 itself. We selected most functions GABRG3 had, and list some proteins which have the same functions with GABRG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to benzodiazepine receptor activity | GABRE,GABRA1,GABRA5,GABRA6A,GABRG1 |
| chloride channel activity | GABRD,GABRR1,GABRG1,TTYH3B,CLCN1,SLC26A4,CLCNKB,GABRA3,GABRP,GABRA2 |
| contributes_to GABA-A receptor activity | GABRZ,GABRA5,GABRR2A,GABRA2,GABRA3,GABRP,GABRA4,GABRA6,GABRQ,GABRR3A |
| inhibitory extracellular ligand-gated ion channel activity | GABRA3,GABRG1,GABRB2,GABRA6A,GABRA6,GABRA4,GABRG2,GABRA2,GABRA5,GABRA1 |
Interacting Protein
GABRG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRG3.
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References
- Wang, XP; Cheng, ZY; et al. GABA(B) receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca2+ concentration. HEART AND VESSELS 30:249-257(2015).
- Cheng, ZY; Wang, XP; et al. GABA(B1) AND GABA(B2) RECEPTOR SUBUNITS CO-EXPRESSED IN CULTURED HUMAN RPE CELLS REGULATE INTRACELLULAR CA(2+) VIA G(I/O)-PROTEIN AND PHOSPHOLIPASE C PATHWAYS. NEUROSCIENCE 280:254-261(2014).
