Gabra5
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 -
Synonyms
GABRA5;gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5;gamma-aminobutyric acid receptor subunit alpha-5;GABAA receptor alpha5 subunit;GABA(A) receptor subunit alpha-5;ligand-gated ion channel subunit;gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5;A230018I05Rik
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- DDK
- Myc
- Avi
- Fc
Involved Pathway
Gabra5 involved in several pathways and played different roles in them. We selected most pathways Gabra5 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabra5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | SLC38A1,PRKACG,GABRE,SLC38A3,GABRB3,GNG12,GNG13,GNG2,GNG11,GABRA6 |
| Nicotine addiction | GABRB1,GRIN3B,GRIN2A,GABRA4,GABRA1,GABRA2,GRIA4,SLC17A8,GABRG2,GABRB3 |
| Neuroactive ligand-receptor interaction | NPY8BR,FSHB,LHB,CHRM5B,GRIN1A,HTR1F,ADRB3A,ADORA1,PTGER3,AGTR1B |
| Retrograde endocannabinoid signaling | GABRG1,GNB4,DAGLB,GABRA1,PTGS2,GNAI1,MAPK13,GNG13,SLC17A8,GNAI2 |
Protein Function
Gabra5 has several biochemical functions, for example, GABA receptor binding,contributes_to GABA-A receptor activity,contributes_to benzodiazepine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabra5 itself. We selected most functions Gabra5 had, and list some proteins which have the same functions with Gabra5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GABA receptor binding | GABARAPL2,PPP2CA,GABARAP,MAF1,JAKMIP1,GABRG1,TRAK1,AKAP5,PLCL2,GABARAPA |
| chloride channel activity | SLC26A6L,GABRG3,GABRA6,CLIC6,SLC26A11,CLCA2,CLCN1,GABRA1,FXYD3,GABRR1 |
| contributes_to GABA-A receptor activity | GABRA6,GABRR3A,GABRG1,GABRA3,GABRA6A,GABRP,GABRQ,GABRZ,GABRR2A,GABRA2 |
| inhibitory extracellular ligand-gated ion channel activity | GABRE,GABRG2,GABRA2,GABRG3,GABRA6A,GABRB2,GABRG1,GABRA3,GABRA6,GABRA4 |
| contributes_to benzodiazepine receptor activity | GABRG3,GABRA1,GABRG1,GABRE,GABRA6A |
| transporter activity | DYF-1,ABCA4,SLC5A8,CRABP2B,MUP3,SLCO1A6,SYPL2A,SLCO2B1,AP1S2,SLC23A3 |
| receptor activity | ADIPOR2,ITGB8,NLGN3B,TLR6,VMN1R52,P2RY11,TNFRSF10A,CSF2RB,THRAP3,IL18R1 |
Interacting Protein
Gabra5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gabra5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gabra5.
Resources
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References
- Ochoa-Lubinoff, CA; Berry-Kravis, EA; et al. Safety and Tolerability of RG1662, a Selective Negative Allosteric Modulator of the GABAA+/-5 Receptor (GABRA5), in Young Adults With Down Syndrome. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 36:S18-S18(2015).
- Khan, WA; Rogan, PK; et al. Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes. MOLECULAR CYTOGENETICS 7:-(2014).
