GAB2
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Official Full Name
GRB2-associated binding protein 2 -
Overview
The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their -
Synonyms
GAB2;GRB2-associated binding protein 2;GRB2-associated-binding protein 2;Grb2 associated binder 2;KIAA0571;pp100;Grb2-associated binder 2;growth factor receptor bound protein 2-associated protein 2
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- T7
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GAB2-2453H | Recombinant Human GAB2 protein, His-tagged | E.coli | Human | His | 111-450 aa | |
| GAB2-2439R | Recombinant Rat GAB2 Protein | Mammalian Cells | Rat | His |
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| GAB2-6074HCL | Recombinant Human GAB2 293 Cell Lysate | HEK293 | Human | Non |
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| Gab2-1851M | Recombinant Mouse Gab2 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln357~Asp607 |
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| GAB2-2095R | Recombinant Rat GAB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GAB2-2095R-B | Recombinant Rat GAB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GAB2-4620H | Recombinant Human GAB2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GAB2-5131HF | Recombinant Full Length Human GAB2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 676 amino acids |
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Involved Pathway
GAB2 involved in several pathways and played different roles in them. We selected most pathways GAB2 participated on our site, such as Ras signaling pathway,Sphingolipid signaling pathway,Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc epsilon RI signaling pathway | MAP2K3,MS4A2,MAPK9,MAP2K1,RAC3,MAPK13,MAPK3,PIK3CD,PLCG2,SYK |
| Ras signaling pathway | PLA2G4F,MAPK1,IGF1R,PIK3CD,GNGT2,GNG4,NFKB1,RALGDS,PIK3R5,PLA2G10 |
| Phospholipase D signaling pathway | PLCB4,PDGFC,GRM6,PIK3R2,PLCB3,FCER1A,INSR,PLD2,AVPR1B,GRM4 |
| Sphingolipid signaling pathway | LASS4,BID,PPP2CA,MAPK3,BAX,PLD2,TNFRSF1A,MAPK10,PPP2R3A,PIK3CB |
| Chronic myeloid leukemia | BCR,MDM2,CRK,PIK3R3,TGFB3,PIK3CA,HRAS,NRAS,PIK3R2,MAP2K2 |
| Osteoclast differentiation | PPP3CC,CSF1R,FCGR3B,MAPK13,MAPK1,IL1A,PPP3R2,FCGR2B,MAP2K1,FOSB |
| Fc gamma R-mediated phagocytosis | PLD1,RPS6KB1,NCF1,PRKCB,HCK,SPHK1,RPS6KB2,PIK3R5,SCIN,VAV1 |
Protein Function
GAB2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding,phosphatidylinositol-3,4-bisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB2 itself. We selected most functions GAB2 had, and list some proteins which have the same functions with GAB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | JUNB,MINK1,MED7,MATN2,ARHGEF3,TAS2R16,VHL,C19orf57,MBP,MNAT1 |
| transmembrane receptor protein tyrosine kinase adaptor activity | SH2B2,TRAT1,IRS1,PIK3R1,STAP1,BLNK,SHC1,FRS2,DOK2 |
| phosphatidylinositol-3,4-bisphosphate binding | ARAP3,MAPKAP1,RS1,TTPA,MYO1G,ANXA8,NCF1,ZFYVE1,PHLDA3,KIF16B |
| phosphatidylinositol-3,4,5-trisphosphate binding | FAM21C,ARAP1,PHLDA3,DAPP1,JPH2,ARAP2,ARAP3,MAPKAP1,D6WSU116E,CYTH3 |
Interacting Protein
GAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB2.
GRB2;PTPN11
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References
- Huang, YJ; Frazier, ML; et al. Reverse-Phase Protein Array Analysis to Identify Biomarker Proteins in Human Pancreatic Cancer. DIGESTIVE DISEASES AND SCIENCES 59:968-975(2014).
- Quintas-Cardama, A; Qiu, YH; et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. CANCER 118:5283-5292(2012).
