FXYD5
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Official Full Name
FXYD domain containing ion transport regulator 5 -
Overview
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. -
Synonyms
FXYD5;FXYD domain containing ion transport regulator 5;FXYD domain-containing ion transport regulator 5;dysadherin;OIT2;keratinocytes associated transmembrane protein 1;RIC;IWU1;KCT1;DYSAD;HSPC113;PRO6241
Recombinant Proteins
- Rat
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
FXYD5 involved in several pathways and played different roles in them. We selected most pathways FXYD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FXYD5 has several biochemical functions, for example, actin binding,cadherin binding,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD5 itself. We selected most functions FXYD5 had, and list some proteins which have the same functions with FXYD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cadherin binding | CTNNB1,CD2AP,NDRG1,MMP24,CDK5R1,NUMB,PSEN1,VCL,PROM1,TRPC4 |
| ion channel activity | KCNC1A,TRPA1A,SCNN1G,NALCN,CATSPER2,TRPV5,GRIA3B,TRPM1,Chrng,CLCN3 |
| sodium channel regulator activity | SCN2B,SCN1BA,FXYD4,SGK2,PRSS30,SCN3B,SGK2A,RANGRF,GPLD1,GPD1L |
| actin binding | CAMK2B,LMOD1,PTK2,MACF1,HIP1,TPM4,DBNLB,SMTNL,MYH8,MYO7A |
Interacting Protein
FXYD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD5.
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