Fxyd1
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Official Full Name
FXYD domain containing ion transport regulator 1 -
Overview
This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. -
Synonyms
FXYD1;FXYD domain containing ion transport regulator 1;phospholemman , PLM;phospholemman;PLM;MGC44983
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Dog
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Fxyd1 involved in several pathways and played different roles in them. We selected most pathways Fxyd1 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fxyd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | HCAR3,GRIA3,GPR81,AKT1,CALML3,GRIN2A,GRIN2D,GLI1,RAC1,RAF1 |
Protein Function
Fxyd1 has several biochemical functions, for example, ATPase binding,chloride channel activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fxyd1 itself. We selected most functions Fxyd1 had, and list some proteins which have the same functions with Fxyd1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium channel regulator activity | SCN2B,PKP2,TMPRSS3,FXYD4,RANGRF,SCN1B,GPLD1,FXYD6,SCN3B,SCLT1 |
| myosin binding | ACTC1,VEZT,STX4A,ARFGEF2,TRIM32,CALD1B,SLC6A4,ACTA1,VETZ,GIPC1 |
| chloride channel activity | ANO2,SLC26A3.2,CLICA,CLCA1,CLCA4,SLC26A6,CLCN1,CLCC1,FXYD3,SLC26A2 |
| ion channel binding | ACTN2,CALM3,HSP90AB1,FAM115A,ASPH,SRI,YWHAQ,RNF207,CALM1,GPD1L |
| ATPase binding | PEX19,DNAJB1,ATP6V0A4,TOR1AIP1,ATP6V1G1,PTPN3,PGR,ATP6V0A1A,FXYD3,ALDOB |
Interacting Protein
Fxyd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fxyd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fxyd1.
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References
- Bibert, S; Liu, CC; et al. FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta(1) Subunit. JOURNAL OF BIOLOGICAL CHEMISTRY 286:18562-18572(2011).
- Wang, JF; Gao, EH; et al. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300:H859-H868(2011).
