FUZ
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Official Full Name
fuzzy homolog -
Synonyms
FUZ;fuzzy homolog (Drosophila);protein fuzzy homolog;FLJ22688;Fy
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- DDK
- Myc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FUZ-2417R | Recombinant Rat FUZ Protein | Mammalian Cells | Rat | His |
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| FUZ-6110HCL | Recombinant Human FUZ 293 Cell Lysate | HEK293 | Human | Non |
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| FUZ-2073R | Recombinant Rat FUZ Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| FUZ-2073R-B | Recombinant Rat FUZ Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Fuz-3111M | Recombinant Mouse Fuz Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| FUZ-4571H | Recombinant Human FUZ Protein, GST-tagged | Wheat Germ | Human | GST |
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| FUZ-5236HF | Recombinant Full Length Human FUZ Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 418 amino acids |
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Involved Pathway
FUZ involved in several pathways and played different roles in them. We selected most pathways FUZ participated on our site, such as DNA Double-Strand Break Repair,DNA Repair,Fanconi Anemia Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | RNF168,BABAM1,KIAA0146,RHNO1,PPP4CA,TP53BP1,RAD1,PPP4R2,TOPBP1,PPP4R2B |
| Homology Directed Repair | PPP4CA,KIAA0146,TOPBP1,RNF4,RHNO1,PPP4CB,EME1,TIMELESS,RAD51AP1,GEN1 |
| Fanconi Anemia Pathway | POLN,FANCI,MLH1,RMI2,FANCL,REV3L,FANCG,USP1,FANCF,FANCB |
| HDR through Homologous Recombination (HRR) | RAD9,RTEL1,RAD9B,TOPBP1,GEN1,RBBP8,HUS1,RHNO1,KIAA0146,RAD51AP1 |
| DNA Double-Strand Break Repair | TDP2B,TDP1,PPP4R2B,RAD9B,HTATIP,TDP2,RTEL1,KIAA0146,RAD50,BAZ1B |
| Homologous recombination | BRCA2,SYCP3,CDK5R2,RAD51D,MRE11A,RAD51,SSBP1,RAD51L1,NBN,RPA4 |
| DNA Repair | TP53BP1,RTEL1,RAD9,COPS2,ALKBH3,CLSPN,INO80E,MAD2L2,ZBTB32,WRN |
Protein Function
FUZ has several biochemical functions, for example, 3-flap endonuclease activity,DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUZ itself. We selected most functions FUZ had, and list some proteins which have the same functions with FUZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MTF1,HOXB13A,NFE2L1A,HOXD4A,ZKSCAN3,RHOXF1,TBPL2,ERCC3,RYBPA,ZFP507 |
| metal ion binding | KCNIP1B,MT1X,PPARG,MT2,ACACB,ASAP2,CLCNKB,ZDHHC6,ZMYND12,TRIM30A |
| protein binding | HSPA1L,TMEM8B,MTMR9,F10,TMEM88,RIPK4,FOXR1,TNP1,POLL,KRTAP10-5 |
| 3-flap endonuclease activity | MUS81 |
Interacting Protein
FUZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUZ here. Most of them are supplied by our site. Hope this information will be useful for your research of FUZ.
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References
- Brooks, ER; Wallingford, JB; et al. Multiciliated Cells. CURRENT BIOLOGY 24:R973-R982(2014).
- Tabler, JM; Barrell, WB; et al. Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF related syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1888-1888(2014).
