FTCD
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Official Full Name
formiminotransferase cyclodeaminase -
Overview
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
FTCD;formiminotransferase cyclodeaminase;formimidoyltransferase-cyclodeaminase;formiminotransferase-cyclodeaminase;formimidoyltransferase cyclodeaminase;LCHC1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Chicken
- Pig
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Insect Cells
- Wheat Germ
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
- MBP
- GST
Involved Pathway
FTCD involved in several pathways and played different roles in them. We selected most pathways FTCD participated on our site, such as Histidine catabolism,Histidine metabolism,Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FTCD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of amino acids and derivatives | SLC25A15,OAZ1,DAO,NAGS,DCT,SLC25A15B,IDO2,TPH2,SLC25A10,PAOX |
| Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | AMDHD1,IDO2,CRYM,UROC1,AFMID,PCBD1,SLC25A21,ACMSD,DLST |
| Histidine catabolism | UROC1,AMDHD1 |
| One Carbon Metabolism | MTHFS,ST20-MTHFS,MTHFD2,ALDH1L1,MTFMT,AHCY |
| Histidine metabolism | ALDH7A1,ALDH2,MAOB,ASPA,ALDH1B1,ALDH9A1,ALDH3B2,ABP1,ALDH9A1A.1,CNDP1 |
| Metabolic pathways | PGAM1A,INPP5L,ALDH3B1,ST3GAL2,LPCAT2,CYP51A1,PAFAH1B1B,ATP5B,CBSB,ACSBG2 |
| Metabolism | PDK2B,TPTE,CEPT1,GGTLC1,Alb,ITPKB,C20orf7,PDP2,PYGMB,AK7A |
| One carbon pool by folate | DHFRL1,MTHFR,MTHFD1B,GART,SHMT1,SHMT2,MTHFD2L,MTHFD2,MTHFD1,ATIC |
Protein Function
FTCD has several biochemical functions, for example, folic acid binding,formimidoyltetrahydrofolate cyclodeaminase activity,formimidoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FTCD itself. We selected most functions FTCD had, and list some proteins which have the same functions with FTCD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| folic acid binding | SLC46A1,DHFR,DMGDH,SLC19A1,MTHFS,TYMS,FOLR3,FOLR1,FOLR2,DAAM2 |
| protein binding | PEPD,XRCC5,LCOR,PCDH17,CD276,IGSF1,JAKMIP1,CTH,SLX4,DNAI2 |
| microtubule binding | RAB11A,KRIT1,SKA1,DNM2,GCAP14,MAP1B,GLI1,NPSNL,DYNC1I1,MAP205 |
Interacting Protein
FTCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FTCD here. Most of them are supplied by our site. Hope this information will be useful for your research of FTCD.
CCDC155;MED4
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References
- Lapierre, P; Beland, K; et al. Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance. HEPATOLOGY 57:217-227(2013).
- Hagiwara, H; Tajika, Y; et al. Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome. HISTOCHEMISTRY AND CELL BIOLOGY 126:251-259(2006).
