FREM2
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Official Full Name
FRAS1 related extracellular matrix protein 2 -
Overview
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014] -
Synonyms
FREM2;FRAS1 related extracellular matrix protein 2;FRAS1-related extracellular matrix protein 2;ECM3 homolog
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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FREM2-6033M | Recombinant Mouse FREM2 Protein | Mammalian Cell | Mouse | His | ||
FREM2-3355M | Recombinant Mouse FREM2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi | ||
FREM2-3355M-B | Recombinant Mouse FREM2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
Involved Pathway
FREM2 involved in several pathways and played different roles in them. We selected most pathways FREM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FREM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein Function
FREM2 has several biochemical functions, for example, calcium ion binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FREM2 itself. We selected most functions FREM2 had, and list some proteins which have the same functions with FREM2. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | SLC25A25B,S100Z,SDF4,PCDH2G4,ATP2C1,DGKA,EFCAB2,DGKAA,NCS1,CAPS |
protein binding | HDGF2,CTTN,KDM5A,NMRK2,WDR61,CCND2,NGDN,ESD,TFDP1,Akap3 |
metal ion binding | ZNF729,ZFP12,ZNF354B,CYP4V7,NT5DC3,ZFP36L2,ZNF583,TH2,REV1,CA5 |
Interacting Protein
FREM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FREM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FREM2.
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References
- Lloreda-Garcia, JM; Gonzalez-Rodriguez, JD; et al. Fraser syndrome caused by a new mutation in the FREM2 gene. ANALES DE PEDIATRIA 82:207-208(2015).
- Biswas, NK; Chandra, V; et al. Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM. SCIENTIFIC REPORTS 5:-(2015).