FOXN4
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Official Full Name
forkhead box N4 -
Overview
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino;acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices;flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key;regulators in development and metabolism (Li et al., 2004 (PubMed 15363391)). -
Synonyms
FOXN4;forkhead box N4;forkhead box protein N4;FLJ35967;Forkhead/winged helix transcription factor FOXN4;FOXN4_HUMAN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXN4-3675C | Recombinant Chicken FOXN4 | Mammalian Cell | Chicken | His |
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| FOXN4-6005M | Recombinant Mouse FOXN4 Protein | Mammalian Cell | Mouse | His |
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| FOXN4-8724Z | Recombinant Zebrafish FOXN4 | Mammalian Cell | Zebrafish | His |
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| FOXN4-3333M | Recombinant Mouse FOXN4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FOXN4-3333M-B | Recombinant Mouse FOXN4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FOXN4 involved in several pathways and played different roles in them. We selected most pathways FOXN4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FOXN4 has several biochemical functions, for example, DNA binding,chromatin binding,enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXN4 itself. We selected most functions FOXN4 had, and list some proteins which have the same functions with FOXN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | DNMT3A,TRP63,NOC2L,EGR2,C10orf119,NKAP,CBFA2T3,LDB2A,GATA6,ATAD2 |
| transcription factor activity, sequence-specific DNA binding | HMGA1,Trl,ATF2,ZRANB2,KLF17,ZNF471,IRF3,STAT2,LHX1A,HOXC6 |
| DNA binding | VDR,ZBTB22,CR2,ZNF738,HOXC13,ZFP35,RARGA,ZEB2,RYBPA,SOX8 |
| sequence-specific DNA binding | HOXB6,SALL3B,DLX4A,TRIM24,ZFP536,PAX3A,RXRGB,PAX7B,SIX4B,NKX6.3 |
| enhancer sequence-specific DNA binding | ATF2,SOX11,KLF6A,TWIST1B,YY1,MYT1,TFAP2B,LDB1,HMGB2,ISL1 |
Interacting Protein
FOXN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXN4.
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References
- Swann, JB; Weyn, A; et al. Conversion of the Thymus into a Bipotent Lymphoid Organ by Replacement of Foxn1 with Its Paralog, Foxn4. CELL REPORTS 8:1184-1197(2014).
- Lee, E; Koo, Y; et al. Autophagy is essential for cardiac morphogenesis during vertebrate development. AUTOPHAGY 10:572-587(2014).
