FOXH1
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Official Full Name
forkhead box H1 -
Overview
Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene. -
Synonyms
FOXH1;forkhead box H1;forkhead box protein H1;FAST 1;Fast 2;Fast-1;Fast-2;FAST1;Fast2;Forkhead activin signal transducer 1;Forkhead activin signal transducer 2;FOX H1;FOXH 1;FOXH1_HUMAN;hFAST 1;hFAST-1;hFAST1;Human homolog of Xenopus forkhead activin signal transducer 1;TGF beta/Activin signal transducer FAST1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXH1-5991M | Recombinant Mouse FOXH1 Protein | Mammalian Cells | Mouse | His |
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| FOXH1-9052Z | Recombinant Zebrafish FOXH1 | Mammalian Cells | Zebrafish | His |
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| FOXH1-6156HCL | Recombinant Human FOXH1 293 Cell Lysate | HEK293 | Human | Non |
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| FOXH1-2562H | Recombinant Human FOXH1 Protein, His-tagged | E.coli | Human | His |
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| FOXH1-3324M | Recombinant Mouse FOXH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| FOXH1-3324M-B | Recombinant Mouse FOXH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FOXH1 involved in several pathways and played different roles in them. We selected most pathways FOXH1 participated on our site, such as Developmental Biology,Heart Development,Regulation of nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Activin | FST,INHBAA,DRAP1,ACVR1C,FSTL3,FSTB |
| TGF-beta Receptor Signaling Pathway | STK11IP,STAMBPL1,HOXD9A,ENG,CTCF,MEF2AA,DAB2,COPS5,ACVRL1,VDRB |
| Signaling by NODAL | LEFTY1,GDF1,TDGF1,DRAP1,ACVR1C,CFC1,PCSK6 |
| Heart Development | HEY1,TBX20,GATA6,FOXC1,FOXC2,HEY2,IRX4,SMYD1,TBX5,NKX2-5 |
| Signal Transduction | STARD8,SOX9A,LPAR5A,GHRH,ARHGAP15,NEDD8,CUL5A,FGD2,DEPDC1B,OR7D2 |
| TGF Beta Signaling Pathway | ZNF423,LEFTY1,FST,ZFP423,ENG,NOG,TGFBR3,RUNX3 |
| Regulation of nuclear SMAD2/3 signaling | SNIP1,MYOD1,CITED1,GSC,CBFB,NKX2,SKI |
| Developmental Biology | TDGF1,DPYSL4,DPYSL5B,DUSP10,FRS3,MED6,NKX2.2A,NR6A1,LGI1B,EVL |
Protein Function
FOXH1 has several biochemical functions, for example, contributes_to DNA binding,R-SMAD binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXH1 itself. We selected most functions FOXH1 had, and list some proteins which have the same functions with FOXH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen receptor binding | CTNNB1,NCOA3,RNF6,EP300,DAXX,PRPF6,Ar,KDM3A,TGFB1I1,GRIP1 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | CDX1,FUBP1,SIX3,SIX6,BACH1,MEOX2,RELA,CUX1,MIXL1,HMGA1 |
| SMAD binding | TGFBR1,BMPR1A,MEF2A,DAB2,TOB1,SKOR1A,YY1,SNW1,COL1A2,BMP2 |
| sequence-specific DNA binding | NKX2.5,BHLHE22,MTPN,DRGX,CEBPD,FOXC2,NKX2-5,EMX1,FOXP1A,MEOX2B |
| transcription regulatory region DNA binding | ATF4,NKX2,ATF3,SOX17,GATA4,NKX3,MTERFD1,SALL2,REST,HIVEP2 |
| RNA polymerase II transcription cofactor activity | CNOT2,MED13A,MED11,TDG,MED7,MED22,MED13L,MED19,MED24,MED15 |
| protein domain specific binding | SERPINB1A,FOXA3,IPCEF1,ESRRA,DDX6,PLAUR,TNFAIP1,MRPL17,PLXND1,MYO7A |
| co-SMAD binding | USP9X,GATA4,TRIM33,SMAD6,SMAD3,TGIF1,SMAD1,SMAD2,CITED1 |
| enhancer binding | SMAD2,AHR,SMAD3,MESP1,TCF3,TCF12,RAI1,LEF1,SP1,TIPARP |
Interacting Protein
FOXH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXH1.
AR;fbe;TCF3;NCK1;PIK3R1;GRB2;SMAD3;SMAD2;TCF12
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References
- Chiu, WT; Le, RC; et al. Genome-wide view of TGF beta/Foxh1 regulation of the early mesendoderm program. DEVELOPMENT 141:4537-4547(2014).
- Nelson, AC; Cutty, SJ; et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC BIOLOGY 12:-(2014).
