FNTB
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Official Full Name
farnesyltransferase, CAAX box, beta -
Overview
Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene. -
Synonyms
FNTB;farnesyltransferase, CAAX box, beta;protein farnesyltransferase subunit beta;FPTB;FTase-beta;CAAX farnesyltransferase subunit beta;ras proteins prenyltransferase subunit beta;MGC31935
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FNTB involved in several pathways and played different roles in them. We selected most pathways FNTB participated on our site, such as Terpenoid backbone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FNTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | PMVK,GGPS1,MVD,FNTA,ACAT2,HMGCRA,ACAT1,MVDA,DHDDS,PCYOX1 |
Protein Function
FNTB has several biochemical functions, for example, drug binding,farnesyltranstransferase activity,isoprenoid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FNTB itself. We selected most functions FNTB had, and list some proteins which have the same functions with FNTB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide binding | CLTA,CTSL2,HCRTR1,ANPEPA,ANG,PPIB,Ctsl,ADNP,RNPEP,RNPEPL1 |
| farnesyltranstransferase activity | GGPS1,COX10 |
| contributes_to protein farnesyltransferase activity | FNTA |
| zinc ion binding | TRIM6,PARP1,MT1X,ZDHHC11,TRIM43B,RORCB,TRIM3,ZMIZ2,LIMS1,QPCTL |
| protein farnesyltransferase activity | FNTA |
| protein binding | RAB11FIP2,WIF1,TRIM63,MAMSTR,CCDC110,LGALSL,SPA17,TAF15,CSF2RB,ZBTB4 |
| drug binding | Alb,DCK,NR1I2,PIGC,PYGB,PPARG,MT2A,CHRNB3,CNR1,TLR7 |
| isoprenoid binding | OLFR49,OLFR50 |
Interacting Protein
FNTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FNTB here. Most of them are supplied by our site. Hope this information will be useful for your research of FNTB.
FNTA;PTP4A3;PTP4A2;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;DYRK1A
Resources
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References
- Chung, JA; Wollack, JW; et al. Purification of prenylated proteins by affinity chromatography on cyclodextrin-modified agarose. ANALYTICAL BIOCHEMISTRY 386:1-8(2009).
- Nguyen, CH; Watts, VJ; et al. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: Implications for adenylyl cyclase 2 signaling. MOLECULAR PHARMACOLOGY 69:1763-1771(2006).
