FMO5
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Official Full Name
flavin containing monooxygenase 5 -
Overview
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. -
Synonyms
FMO5;flavin containing monooxygenase 5;dimethylaniline monooxygenase [N-oxide-forming] 5;Dimethylaniline monooxygenase [N oxide forming] 5;Dimethylaniline oxidase 5;FMO 5;Hepatic flavin containing monooxygenase 5;OTTHUMP00000016306;OTTHUMP00000016307;OTTHUMP00000231953;OTTHUMP00000231954;hepatic flavin-containing monooxygenase 5
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FMO5 involved in several pathways and played different roles in them. We selected most pathways FMO5 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - cytochrome P | UGT2B7,GSTP2,GSTT1B,UGT1A7C,UGT1A1,MGST2,GSTM2,FMO3,UGT1A6,UGT1A3 |
Protein Function
FMO5 has several biochemical functions, for example, N,N-dimethylaniline monooxygenase activity,NADP binding,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO5 itself. We selected most functions FMO5 had, and list some proteins which have the same functions with FMO5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N,N-dimethylaniline monooxygenase activity | FMO3,FMO1,FMO2 |
| NADP binding | MTHFR,NNT,NOS2,NDOR1,NOS3,CRYM,G6PD,NOS1,GAPDHS,MTRR |
| flavin adenine dinucleotide binding | ACADL,SDHA,LDHD,DUS4L,AIFM2,TXNRD3,KDM1B,SQLE,DMGDH,GSR |
Interacting Protein
FMO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO5.
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References
- Shalaby, EM; Girgis, AS; et al. Regioselective synthesis, stereochemical structure, spectroscopic characterization and geometry optimization of dispiro[3H-indole-3, 2 '-pyrrolidine-3 ',3 ''-piperidines]. JOURNAL OF MOLECULAR STRUCTURE 1075:327-334(2014).
- Xie, G; Cheng, KW; et al. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent. BIOCHEMICAL PHARMACOLOGY 91:249-255(2014).
