FLIP
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Official Full Name
FLIP α (C-terminus) -
Overview
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed α, β, γ, δ, respectively. -
Synonyms
FLIP;c FLIPL;c FLIPR;c FLIPS;c-FLIP;CASH;CASP8 and FADD like apoptosis regulator;CASP8 and FADD like apoptosis regulator precursor;CASP8 and FADD-like apoptosis regulator subunit p12;CASP8;CASP8AP1;Caspase Eight Related Protein antibody;Caspas
Recombinant Proteins
- Bacillus subtilis
- Buchnera aphidicola subsp. Baizongia pistaciae
- Buchnera Aphidicola Subsp. Schizaphis Graminum
- Rhodobacter Sphaeroides
- Borrelia Burgdorferi
- Pseudomonas aeruginosa
- Caulobacter crescentus
- E.coli
- Salmonella typhimurium
- Aquifex Aeolicus
- Treponema Pallidum
- Buchnera aphidicola subsp. Acyrthosiphon pisum
- Rhizobium Meliloti
- Pectobacterium carotovorum
- Agrobacterium Fabrum
- Treponema denticola
- E. coli or Yeast
- E.coli expression system
- His
Involved Pathway
FLIP involved in several pathways and played different roles in them. We selected most pathways FLIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FLIP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FLIP itself. We selected most functions FLIP had, and list some proteins which have the same functions with FLIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
FLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of FLIP.
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