FCRL5
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Official Full Name
Fc receptor-like 5 -
Overview
Fc receptor homologs (FcRH5), also known as IRTA2 proteins, are transmembrane proteins with sequence homology to classical Fc receptor families. FcRH5 function as activating or inhibitory receptors on discrete B cell populations and are involved in B-cell development and differentiation in peripheral lymphoid organs. FcRH5 expression is deregulated in multiple myeloma and Burkitt lymphoma cell lines with 1q21 abnormalities. FcRH5 may play a critical role for the pathogenesis of B-cell lymphoma. -
Synonyms
FCRL5;Fc receptor-like 5;Fc receptor-like protein 5;BXMAS1;CD307e;FCRH5;IRTA2;fcR-like protein 5;fc receptor homolog 5;immune receptor translocation-associated protein 2;immunoglobulin superfamily receptor translocation associated 2 (IRTA2);CD307;PRO820;FLJ00333;FLJ00397;RP11-217A12.1;MGC119590;MGC119592;MGC119593;DKFZp667F216;DKFZp667E2019
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- HEK293
- Mammalian Cells
- C-His
- Wheat Germ
- In Vitro Cell Free System
- His
- Avi
- Non
- Fc
- hIgG4
- GST
Involved Pathway
FCRL5 involved in several pathways and played different roles in them. We selected most pathways FCRL5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FCRL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FCRL5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FCRL5 itself. We selected most functions FCRL5 had, and list some proteins which have the same functions with FCRL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
FCRL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCRL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCRL5.
Resources
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References
- Franco, A; Damdinsuren, B; et al. Human Fc Receptor-Like 5 Binds Intact IgG via Mechanisms Distinct from Those of Fc Receptors. JOURNAL OF IMMUNOLOGY 190:5739-5746(2013).
- Elkins, K; Zheng, B; et al. FcRL5 as a Target of Antibody-Drug Conjugates for the Treatment of Multiple Myeloma. MOLECULAR CANCER THERAPEUTICS 11:2222-2232(2012).
