FBXW5
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Official Full Name
F-box and WD repeat domain containing 5 -
Overview
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. -
Synonyms
FBXW5;F-box and WD repeat domain containing 5;F box and WD 40 domain protein 5;F-box/WD repeat-containing protein 5;DKFZP434B205;Fbw5;MGC20962;F box and WD 40 domain containing protein 5;F box and WD repeat domain containing 5;F-box and WD-40 domain protein 5;WD repeat-containing F-box protein FBW5;F-box and WD-40 domain-containing protein 5;RP11-229P13.10
Recombinant Proteins
- Zebrafish
- Rat
- Chicken
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXW5-12506Z | Recombinant Zebrafish FBXW5 | Mammalian Cells | Zebrafish | His |
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| FBXW5-2303R | Recombinant Rat FBXW5 Protein | Mammalian Cells | Rat | His |
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| FBXW5-2397C | Recombinant Chicken FBXW5 | Mammalian Cells | Chicken | His |
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| FBXW5-3973H | Recombinant Human FBXW5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXW5-5779M | Recombinant Mouse FBXW5 Protein | Mammalian Cells | Mouse | His |
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| FBXW5-610HCL | Recombinant Human FBXW5 cell lysate | Human | Non |
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| FBXW5-1960R | Recombinant Rat FBXW5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FBXW5-1960R-B | Recombinant Rat FBXW5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| FBXW5-3179M | Recombinant Mouse FBXW5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXW5-3179M-B | Recombinant Mouse FBXW5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXW5-4717HF | Recombinant Full Length Human FBXW5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 159 amino acids |
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Involved Pathway
FBXW5 involved in several pathways and played different roles in them. We selected most pathways FBXW5 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis,Chaperonin-mediated protein folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Association of TriC/CCT with target proteins during biosynthesis | CCT5,NOP56,FKBP9,TCP1,FBXL5,CCT4,CCT3,FBXW4,KIFC3,FBXW9 |
| Chaperonin-mediated protein folding | TUBB4A,PFDN5,TUBA3D,TUBA1B,CCT6A,FBXL5,PFDN2,TCP1,PFDN4,PFDN6 |
| Protein folding | FKBP9,ARL2,TBCB,TBCA,FBXW4,FBXW9,VBP1,PFDN5,FBXW2,NOP56 |
| Metabolism of proteins | NAPAB,GZMH,NAPB,COX17,PDIA6,GATA6,MUC20,UBA2,DPP4,ARSI |
Protein Function
FBXW5 has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW5 itself. We selected most functions FBXW5 had, and list some proteins which have the same functions with FBXW5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | TCTN2,LAX1,CAV1,NEK6,BAG5,DNM2,KCNA5,SPAG16,CD24,PTPRJ |
| protein binding | NEK9,HIST1H4C,HNRNPM,C7orf59,DDAH2,PSMB5,KITLG,FAM109B,PURA,SCG5 |
Interacting Protein
FBXW5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW5.
SKP1;TRIM27;KRTAP10-8;KRT31;KRT40;ADAMTSL4
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References
- Ha, JY; Kim, JS; et al. Tnfaip8 l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. JOURNAL OF NEUROCHEMISTRY 129:527-538(2014).
- Kim, TY; Jackson, S; et al. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:16868-16873(2013).
