FBXL6
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Official Full Name
F-box and leucine-rich repeat protein 6 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. -
Synonyms
FBXL6;F-box and leucine-rich repeat protein 6;F-box/LRR-repeat protein 6;FBL6;F box and leucine rich repeat protein 6;F box protein FBL 6;F box protein FBL6;F box/LRR repeat protein 6;FBL 6;FBL 6A;FBL6A;FbxL 6;PP 14630;PP14630;F-box protein Fbl6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL6-3909H | Recombinant Human FBXL6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXL6-5726M | Recombinant Mouse FBXL6 Protein | Mammalian Cells | Mouse | His |
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| FBXL6-601HCL | Recombinant Human FBXL6 cell lysate | Human | Non |
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| FBXL6-3150M | Recombinant Mouse FBXL6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXL6-3150M-B | Recombinant Mouse FBXL6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXL6-5004HF | Recombinant Full Length Human FBXL6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 539 amino acids |
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Involved Pathway
FBXL6 involved in several pathways and played different roles in them. We selected most pathways FBXL6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FBXL6 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL6 itself. We selected most functions FBXL6 had, and list some proteins which have the same functions with FBXL6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | RNF220,CBLL1,ARIH2,BIRC8,CNOT4B,RNF151,BIRC5B,TRIM71,DZIP3,NSMCE1 |
| contributes_to ubiquitin protein ligase activity | ANAPC2,FBXL20,SKP2,FBXL14A,FBXL14,CUL1B,FBXL22,C10orf46,CUL4B,FBXL4 |
Interacting Protein
FBXL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL6.
SKP1;Srp72;UBE2A;Eif3e;HNRNPU;Naa50;Rpl35;Spire2;CAMKK1;GSG2;KBTBD7;TFG;NLRP3;MPHOSPH8;Rrbp1;Mad2l1bp;Cenph;Sart1
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References
- Hwang, CY; Kim, K; et al. Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ. PROTEOMICS 14:121-132(2014).
- Hu, TZ; Yang, YW; et al. Transgenic pepper plants carrying RNA interference constructs of CaCOI1 gene show severe abnormality. MOLECULAR BREEDING 31:971-979(2013).
