FANCE
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Official Full Name
Fanconi anemia, complementation group E -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. -
Synonyms
FANCE;Fanconi anemia, complementation group E;FACE;Fanconi anemia group E protein;FAE;2810451D06Rik;AI415634;AW209126;FANCE_HUMAN;Fanconi anemia complementation group E;Protein FACE;RGD1561045;OTTHUMP00000016254
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCE-3810Z | Recombinant Zebrafish FANCE | Mammalian Cell | Zebrafish | His |
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| FANCE-3830H | Recombinant Human FANCE Protein, GST-tagged | Wheat Germ | Human | GST |
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| FANCE-594HCL | Recombinant Human FANCE cell lysate | Human | Non |
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| FANCE-4665HF | Recombinant Full Length Human FANCE Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 536 amino acids |
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Involved Pathway
FANCE involved in several pathways and played different roles in them. We selected most pathways FANCE participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | FUZ,RPA4,CDK5R2,ERCC1,UBE2T,ZBTB32,RPA2,HES1,USP1,FANCM |
Protein Function
FANCE has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCE itself. We selected most functions FANCE had, and list some proteins which have the same functions with FANCE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | MRPL47,DOPEY2,Armc3,WDR74,SSUH2.3,ICA1,TMEM57B,GM9524,CCDC113,SCFD2 |
Interacting Protein
FANCE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCE here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCE.
FANCC;FANCD2;Fancc;Erh;FANCD2;FANCG;FANCA;FANCF
Resources
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References
- Huang, YL; Leung, JWC; et al. Modularized Functions of the Fanconi Anemia Core Complex. CELL REPORTS 7:1849-1857(2014).
- Polito, D; Cukras, S; et al. The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 289:7003-7010(2014).
