FANCD2
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Official Full Name
Fanconi anemia, complementation group D2 -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
FANCD2;Fanconi anemia, complementation group D2;FA4;FAD;FACD;FAD2;FA-D2;FANCD;Fanconi anemia group D2 protein
Recombinant Proteins
- Zebrafish
- Rat
- Chicken
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCD2-11486Z | Recombinant Zebrafish FANCD2 | Mammalian Cell | Zebrafish | His |
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| FANCD2-2269R | Recombinant Rat FANCD2 Protein | Mammalian Cell | Rat | His |
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| FANCD2-3326C | Recombinant Chicken FANCD2 | Mammalian Cell | Chicken | His |
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| FANCD2-270HCL | Recombinant Human FANCD2 lysate | HEK293 | Human | Non |
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| FANCD2-1459H | Recombinant Human FANCD2 Protein, His-tagged | E.coli | Human | His | Met1-Thr359 |
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| FANCD2-1926R | Recombinant Rat FANCD2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FANCD2-1926R-B | Recombinant Rat FANCD2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
FANCD2 involved in several pathways and played different roles in them. We selected most pathways FANCD2 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | POLK,RPA1,SLX1B,FUZ,EME1,BRCA1,HER6,ATRIP,PMS2,DCLRE1A |
Protein Function
FANCD2 has several biochemical functions, for example, DNA polymerase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCD2 itself. We selected most functions FANCD2 had, and list some proteins which have the same functions with FANCD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PTK2B,GNB2,GATA1,PRKCB,RNASEL,XRCC4,SNTA1,TCF25,GNGT1,GNAQ |
| DNA polymerase binding | HMGB1,SMARCA4,RAD51,ACD,PCNA,FANCI,LONP1,CDK2AP1 |
Interacting Protein
FANCD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCD2.
BRCA2;MRE11A
Resources
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References
- Duan, WR; Gao, L; et al. Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents. TRANSLATIONAL RESEARCH 161:156-164(2013).
- Alexander, BM; Wang, XZ; et al. DNA Repair Biomarkers Predict Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 83:164-171(2012).
