FANCB
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Official Full Name
Fanconi anemia, complementation group B -
Overview
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. -
Synonyms
FANCB;Fanconi anemia, complementation group B;Fanconi anemia group B protein;FAAP95;FAB;FLJ34064;Fanconi anemia-associated polypeptide of 95 kDa;FA2;FACB;FAAP90
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FANCB-27930TH | Recombinant Human FANCB | Wheat Germ | Human | Non | 109 amino acids |
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| FANCB-3812Z | Recombinant Zebrafish FANCB | Mammalian Cells | Zebrafish | His |
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| FANCB-3826H | Recombinant Human FANCB Protein, GST-tagged | Wheat Germ | Human | GST |
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| FANCB-4236C | Recombinant Chicken FANCB | Mammalian Cells | Chicken | His |
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| FANCB-593HCL | Recombinant Human FANCB cell lysate | Human | Non |
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| FANCB-4663HF | Recombinant Full Length Human FANCB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 859 amino acids |
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Involved Pathway
FANCB involved in several pathways and played different roles in them. We selected most pathways FANCB participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | MLH1,WDR48,TOP3B,RMI1,POLI,PALB2,BRCA1,FANCG,RPA3,ATRIP |
Protein Function
FANCB has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCB itself. We selected most functions FANCB had, and list some proteins which have the same functions with FANCB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CAMK1,LGALS2,TMSB10,BTK,RNF135,ZNF394,HIST2H3C,ELMO2,ZNF256,COA5 |
Interacting Protein
FANCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCB here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCB.
FAAP100;Fancc;Faap100;FANCG;FANCA;FANCM;FANCL
Resources
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References
- Kim, TM; Son, MY; et al. RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. NUCLEIC ACIDS RESEARCH 43:893-903(2015).
- Shapira, I; Scheiner, J; et al. FREQUENT SINGLE NUCLEOTIDE POLYMORPHISMS IN GERM LINE DNA OF CDK4, FANCB, FANCC AND MEN1 ARE SEEN IN BREAST CANCER PATIENTS. JOURNAL OF INVESTIGATIVE MEDICINE 63:584-584(2015).
