EYA3
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Official Full Name
eyes absent homolog 3 -
Overview
EYA3 (eyes absent homolog 3) functions as a tyrosine phosphatase that specifically dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph). EYA3 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes co -
Synonyms
EYA3;eyes absent homolog 3 (Drosophila);eyes absent (Drosophila) homolog 3;eyes absent homolog 3;DKFZp686C132;eyes absent 3
Recombinant Proteins
- Rhesus macaque
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EYA3-1526R | Recombinant Rhesus monkey EYA3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| EYA3-26817TH | Recombinant Human EYA3 | Wheat Germ | Human | Non | 103 amino acids |
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| EYA3-3593H | Recombinant Human EYA3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EYA3-4993Z | Recombinant Zebrafish EYA3 | Mammalian Cells | Zebrafish | His |
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| EYA3-5398M | Recombinant Mouse EYA3 Protein | Mammalian Cells | Mouse | His |
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| EYA3-1351R | Recombinant Rhesus Macaque EYA3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| EYA3-1351R-B | Recombinant Rhesus Macaque EYA3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| EYA3-2911M | Recombinant Mouse EYA3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| EYA3-2911M-B | Recombinant Mouse EYA3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EYA3-4458HF | Recombinant Full Length Human EYA3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 536 amino acids |
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Involved Pathway
EYA3 involved in several pathways and played different roles in them. We selected most pathways EYA3 participated on our site, such as DNA Double Strand Break Response,DNA Double-Strand Break Repair,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EYA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double-Strand Break Repair | RAD17,EYA4,CHEK1,EME2,KDM4A,BABAM1,TIMELESS,RTEL1,RAD50,TIPIN |
| DNA Repair | CHEK2,RNF4,TOPBP1,ELL,RAD17,PPP4CB,RAD9B,KDM4A,INO80E,PARP2 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | EYA4,BAZ1B,EYA2,KDM4A,KDM4B |
| DNA Double Strand Break Response | CHEK2,BARD1,THRSP,KDM4B,FAM175A,UIMC1,TP53BP1,BAZ1B,RNF168,EYA4 |
Protein Function
EYA3 has several biochemical functions, for example, chromatin binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EYA3 itself. We selected most functions EYA3 had, and list some proteins which have the same functions with EYA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | CYP46A1.2,CNDP1,GUCA1D,RARAB,PARP12A,ZBTB24,ZNF839,ANKFY1,GNPTAB,ERI3 |
| protein binding | EPAS1,PGF,C1orf182,FRK,RUNX1T1,JAM3B,IFT27,PTPN22,FBXL14,NTN1 |
| chromatin binding | LRWD1,BRD4,DLX3,AIRE,SSRP1A,SMAD6,HDGFRP2,NR5A1B,MEF2A,LDB1 |
| protein tyrosine phosphatase activity | DUSP19,PGP,DUSP11,EYA2,CDC14AB,PTPRO,PTPN2,PTPRA,CDKN3,MTMR7B |
| protein tyrosine/serine/threonine phosphatase activity | TPTE,DUSP2,CDC14AA,DUSP26,DUSP22,CDC14B,PTENA,PTENB,PXYLP1,DUSP19A |
Interacting Protein
EYA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EYA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EYA3.
CRK;ZDHHC17
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References
- Majumdar, G; Rani, S; et al. Hypothalamic gene switches control transitions between seasonal life history states in a night-migratory photoperiodic songbird. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:110-121(2015).
- Ashbrook, DG; Delprato, A; et al. Transcript co-Variance With Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor Cell proliferation in the adult hippocampus. FRONTIERS IN NEUROSCIENCE 8:-(2014).
