EXOSC6
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Official Full Name
exosome component 6 -
Overview
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. -
Synonyms
EXOSC6;exosome component 6;exosome complex component MTR3;EAP4;hMtr3p;MTR3;Mtr3 (mRNA transport regulator 3) homolog (yeast);Mtr3p;p11;hMtr3;homolog of yeast mRNA transport regulator 3;Mtr3 (mRNA transport regulator 3)-homolog;exosome complex exonuclease MTR3;mRNA transport regulator 3 homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EXOSC6-2689Z | Recombinant Zebrafish EXOSC6 | Mammalian Cell | Zebrafish | His |
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| EXOSC6-3577H | Recombinant Human EXOSC6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EXOSC6-5386M | Recombinant Mouse EXOSC6 Protein | Mammalian Cell | Mouse | His |
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| EXOSC6-2904M | Recombinant Mouse EXOSC6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EXOSC6-2904M-B | Recombinant Mouse EXOSC6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
EXOSC6 involved in several pathways and played different roles in them. We selected most pathways EXOSC6 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | CNOT3A,PFKL,PAPD7,LSM8,PARN,TOB1B,groL,BTG1,BTG2,PFKM |
Protein Function
EXOSC6 has several biochemical functions, for example, RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC6 itself. We selected most functions EXOSC6 had, and list some proteins which have the same functions with EXOSC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | EIF2S1A,PPP1R8,DAZAP1,PPARGC1B,HNRNPA2B1,RCAN3,PABPC1A,TRIM71,CWC15,EYA1 |
| poly(A) RNA binding | MSI1,C11orf68,SNRPN,PPIE,IGF2BP2,RPL17,HNRNPR,KTN1,TBL2,RBM28 |
Interacting Protein
EXOSC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC6.
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