ERVWE1
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Official Full Name
endogenous retrovirus group W, member 1 -
Overview
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
endogenous retroviral family W, env(C7), member 1;envelope glycoprotein;HERVW;envelope protein;HERV-7q;enverin;HERV-W-ENV;HERV-tryptophan envelope protein;Envelope polyprotein gPr73;HERV-W Env glycoprotein;HERV-7q Envelope protein;HERV-W_7q21.2 provirus ancestral Env polyprotein;HERV-W envelope protein;HERV-W{7q21.1} provirus ancestral Env polyprotein;HERV-W;human endogenous retrovirus W envC7-1 envelope protein;ENV;syncytin A;ENVW;syncytin-1;HERV7Q;Env-W;HERVWENV;OTTHUMP00000161914;Syncytin;ERVWE1;endogenous retrovirus group W member 1
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Involved Pathway
ERVWE1 involved in several pathways and played different roles in them. We selected most pathways ERVWE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ERVWE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
ERVWE1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ERVWE1 itself. We selected most functions ERVWE1 had, and list some proteins which have the same functions with ERVWE1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ERVWE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERVWE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERVWE1.
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