ERG
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Official Full Name
v-ets avian erythroblastosis virus E26 oncogene homolog -
Overview
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewings sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] -
Synonyms
ERG;v-ets avian erythroblastosis virus E26 oncogene homolog;p55;erg-3;transcriptional regulator ERG;ets-related;TMPRSS2/ERG fusion;v-ets erythroblastosis virus E26 oncogene like;v-ets erythroblastosis virus E26 oncogene homolog;v-ets avian erythroblastosis virus E26 oncogene related;transcriptional regulator ERG (transforming protein ERG)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Flag
- His&T7
- His&Flag
- GST
- Non
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ERG involved in several pathways and played different roles in them. We selected most pathways ERG participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HOXA9,TRAF1,PER2,H3F3B,BCL6,FUS,TFE3,IL2RB,MMP3,ZBTB17 |
Protein Function
ERG has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERG itself. We selected most functions ERG had, and list some proteins which have the same functions with ERG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPA3,DZIP1,BRAF,FAM195A,FBLIM1,ZNF543,NINJ1,NFKBIZ,ICA1,PRPF31 |
| chromatin binding | HOXC13,TRIM24,HMGXB4A,LDB1,APITD1,RELA,GATA1A,ZMYND11,HINFP,PPARG |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXR2,FOXB1,FOXD2,HIF1AL,HIF1AB,MITFB,EF1,ZNF488,FOXJ1A,FOXA3 |
| signal transducer activity | MRGPRA7,OLFR5,GRM6B,OPN4B,TAAR12B,GPR34A,STAT3,SP110,MAPKAPK2A,MGAA |
| DNA binding | FOSL1A,ZBTB44,DNASE2,HOXA1A,MLXIPL,EEF1D,THAP7,TIGD6,RCAN1,RB1 |
| sequence-specific DNA binding | TBX5,FOXN2,BARHL1A,BCL11B,ZNF215,ELF2,POU2F1,NFIL3-6,LHX8,TBX1 |
Interacting Protein
ERG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERG here. Most of them are supplied by our site. Hope this information will be useful for your research of ERG.
AR;PARP1;fkbp5_human_gene;klk3_human_gene;tmps2_human_gene
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References
- Shon, W; Folpe, AL; et al. ERG expression in chondrogenic bone and soft tissue tumours. JOURNAL OF CLINICAL PATHOLOGY 68:125-129(2015).
- Brenn, T; et al. Cutaneous angiosarcoma. New aspects. PATHOLOGE 36:70-77(2015).
