ERCC6L

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 6-like

  • Overview

    Plk1-interacting checkpoint helicase (PICH ) is an essential component of the spindle assembly checkpoint (Baumann, C., et al. (2007). Cell 128:101–114). This protein is an ATPase family SNF2 member, and serves as a binding partner and substrate for Plk1. When PICH is phosphorylated, it retrieves Plk1 which serves to mediate the localization of PICH. As a DNA helicase, PICH gathers at kinetochores and centromeres during prometaphase, acting as a necessary part of the spindle assembly checkpoint by recruiting MAD2 and mediating chromatin centromeric tension. Depleted PICH results in the cancellation of the spindle checkpoint causing large scale missegregation of the chromosome.

  • Synonyms

    ERCC6L;excision repair cross-complementing rodent repair deficiency, complementation group 6-like;DNA excision repair protein ERCC-6-like;FLJ20105;PICH;PLK1 interacting checkpoint helicase;tumor antigen BJ-HCC-15;SNF2/RAD54 family protein;ATP-dependent helicase ERCC6-like;excision repair protein ERCC6-like;Plk1-interacting checkpoint helicase;excision repair cross-complementing rodent repair deficiency complementation group 6 - like;MGC131695

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ERCC6L-3462H Recombinant Human ERCC6L Protein, GST-tagged Wheat Germ Human GST
ERCC6L-5290M Recombinant Mouse ERCC6L Protein Mammalian Cell Mouse His
ERCC6L-5868Z Recombinant Zebrafish ERCC6L Mammalian Cell Zebrafish His
ERCC6L-634HCL Recombinant Human ERCC6L cell lysate Human Non
ERCC6L-2844M Recombinant Mouse ERCC6L Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ERCC6L-2844M-B Recombinant Mouse ERCC6L Protein Pre-coupled Magnetic Beads HEK293 Mouse
ERCC6L-392HF Recombinant Human ERCC6L protein, His-tagged E.coli Human His 832-1250 aa
ERCC6L-4562HF Recombinant Full Length Human ERCC6L Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 419 amino acids

    Involved Pathway

    ERCC6L involved in several pathways and played different roles in them. We selected most pathways ERCC6L participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitotic Metaphase and Anaphase CENPL,NDEL1A,CENPP,RCC2,VRK2,MLF1IP,SGOL2,TMPO,ANKLE2,PMF1
    Cell Cycle, Mitotic NCAPH2,ARPP19B,CP110,CEP152,TCTN2,CENPQ,LMNB1,BANF1,MAPRE1B,GINS3
    Mitotic Anaphase CENPH,SKA2,TMPO,CENPI,CDCA8,MLF1IP,CENPP,NUF2,ZW10,CENPK
    PLK1 signaling events BORA,TCTN2,PLK1S1,TPX2,TPT1,NDC80,SPC24,ECT2
    Cell cycle CEP70,MCM4,CLIP1,GADD45B,DBF4,UBE2V2,DNA2,DYNC1I2,POT1,RBL1
    RHO GTPase Effectors RHPN2,PRC1B,RANGAP1B,CIT,NOXO1,IQGAP3,WIPF3,CDCA8,NUF2,SGOL2
    M Phase TMPO,KNTC1,NDEL1A,SPC25,CENPQ,STAG2,NCAPH2,CENPP,CENPC1,CENPE
    Mitotic Prometaphase NUF2,SPDL1,RCC2,PANE1,SPC24,ZW10,SMC4,CENPL,RANGAP1B,CLIP1

    Protein Function

    ERCC6L has several biochemical functions, for example, ATP binding,DNA binding,helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6L itself. We selected most functions ERCC6L had, and list some proteins which have the same functions with ERCC6L. You can find most of the proteins on our site.

    Function Related Protein
    helicase activity PL10,MCM6L,DDX39AA,SHPRH,MCM3L,HLTF,ATRX,DDX52,DHX33,EIF4A1
    ATP binding ATP1A1B,MVK,NME7,SBK3,TNIKB,GTF2F2,AKT3,RAD54L,PAPSS2B,ACVR1L
    DNA binding ETS2,POLR3H,MXTX2,PML,KDM2BA,RAG1,OASL,ESRRA,RXRBA,KCNA3
    protein binding ADM,DFFA,KAT2A,NEK11,NCKAP1L,BMP4,PLAA,PNMA5,ANK2,CTNNA2

    Interacting Protein

    ERCC6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6L here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6L.

    LMO4;PLK1;HTT;RPA3;Plk1;Ercc6l;RB1CC1;ZDHHC17;LDHA;EIF4B;BLM;TOP3A;CDC5L;RMI1

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