ERCC5
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Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 5 -
Overview
This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. -
Synonyms
ERCC5;excision repair cross-complementing rodent repair deficiency, complementation group 5;ERCM2, xeroderma pigmentosum, complementation group G , XPGC;DNA repair protein complementing XP-G cells;Cockayne syndrome;COFS 3;COFS3;DNA excision repair protein ERCC 5;DNA excision repair protein ERCC5;DNA repair protein complementing XP G cells;DNA repair protein complementing XPG cells;ERCC 5;ERCM 2;ERCM2;Excision Repair Cross Complementing Rodent Repair Deficiency;Excision repair cross complementing rodent repair deficiency complementation group 5;Excision repair protein;OTTHUMP00000064902;UVDR;Xeroderma Pigmentosum Complementation Group G;Xeroderma pigmentosum complementation group G protein;Xeroderma pigmentosum group G complementing protein;XPG;XPG complementing protein;XPGC;OTTHUMP00000018678;XPG-complementing protein;DNA excision repair protein ERCC-5;xeroderma pigmentosum, complementation group G
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
ERCC5 involved in several pathways and played different roles in them. We selected most pathways ERCC5 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | POLE3,INO80B,RPA1,GTF2H2,KIAA1530,GTF2H3,RAD23B,COPS3,COPS7B,ACTR5 |
Protein Function
ERCC5 has several biochemical functions, for example, bubble DNA binding,double-stranded DNA binding,endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC5 itself. We selected most functions ERCC5 had, and list some proteins which have the same functions with ERCC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZFP106,ADAMTS7,MUL1A,Fcer2a,FOXP1,TGFBR2,CYB561D2,HPD,ZDHHC23B,LNX2A |
| protein homodimerization activity | HMGCR,ZFP652,PVRL3B,TMEM192,TRPM8,TDG,CCDC103,SYT10,TMEM173,IRAK2 |
| protein binding | SH3GLB1,CNOT3,NCSTN,AP3S1,HIST1H4B,XRN1,CYB5R2,TROAP,BBS1,FAM124B |
| bubble DNA binding | RECQL4,BLM,HMGB1,NEIL3,WRN |
| double-stranded DNA binding | MEN1,TDP1,SATB1,TRP63,XRCC5,GATA1A,EGFR,TP63,MTERF,HNRNPDL |
| single-stranded DNA binding | MLH3,NCL,NABP2,RAD51L1,PCBP1,XRCC2,CRY2,LUZP4,MCM6,RAD51AP1 |
| endodeoxyribonuclease activity | DNASE1L2,DNASE1L1,DNASE1L3,RPS3,APLF,DNASE1L3L,APEX1,MRE11A,DNASE1,ERCC4 |
| protein N-terminus binding | VWF,GTF2H2,MEN1,SLC6A3,KCNQ2,HDAC1,GTF2H3,RND2,ACOX1,RBPJ |
Interacting Protein
ERCC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC5.
HSPB1;EWSR1;Tpx2;BCL6;LRPPRC;CDK7;Kif1bp;GTF2H5;TGS1;Ndc80
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