ERCC4
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Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 4 -
Overview
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5 incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6). -
Synonyms
ERCC4;excision repair cross-complementing rodent repair deficiency, complementation group 4;XPF;DNA repair endonuclease XPF;RAD1;xeroderma pigmentosum;complementation group F;DNA excision repair protein ERCC-4;DNA repair protein complementing XP-F
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERCC4-3826H | Recombinant Human ERCC4 protein, His-tagged | E.coli | Human | His | 658-753 aa | |
| ERCC4-10173Z | Recombinant Zebrafish ERCC4 | Mammalian Cell | Zebrafish | His |
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| ERCC4-6564HCL | Recombinant Human ERCC4 293 Cell Lysate | HEK293 | Human | Non |
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| ERCC4-1928HFL | Recombinant Full Length Human ERCC4 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| Ercc4-2853M | Recombinant Mouse Ercc4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ERCC4-5573H | Recombinant Human ERCC4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| ERCC4-861H | Recombinant Human ERCC4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ERCC4-861H-B | Recombinant Human ERCC4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
ERCC4 involved in several pathways and played different roles in them. We selected most pathways ERCC4 participated on our site, such as Nucleotide excision repair,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | CCNH,YY1A,INO80,ERCC6,ACTR5,INO80C,POLD1,KIAA1530,RAD23AB,USP45 |
| Fanconi Anemia Pathway | SLX4,CDK5R2,STRA13,RAD51C,RPA4,FANCG,MUS81,FAN1,FANCL,SLX1B |
Protein Function
ERCC4 has several biochemical functions, for example, TFIID-class transcription factor binding,damaged DNA binding,endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC4 itself. We selected most functions ERCC4 had, and list some proteins which have the same functions with ERCC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | HMGB2,ALYREF,TEN1,NABP1A,HNRNPK,RPA4,TDP2B,RAD51,RAD23A,BLM |
| protein C-terminus binding | SIAH1A,MAP3K7,KPNA3,PPM1A,VGLL3,CDK7,MPDZ,SIRT1,NEIL1,ERCC1 |
| protein N-terminus binding | PARP1,FEZ1,ERCC2,EXOC5,PDCD10,TAF11,NBN,TRAF6,TDRD7,UNC13A |
| endodeoxyribonuclease activity | ZRANB3,DNASE1,DNASE1L3L,MRE11A,APEX1,ERCC5,DNASE2A,DNASE1L2,RPS3,DNASE1L1 |
| TFIID-class transcription factor binding | FBL,ZNHIT6,NOP58,ERCC1 |
| protein binding | ETL4,PLN,FBXO9,CYLD,FASLG,UBE2K,MYLIP,NAPB,COX6B2,ARMCX5 |
| damaged DNA binding | NEIL3,XPC,HMGB1,PNKP,TP73,RPA2,MPG,TDG,XRCC6,FANCG |
| contributes_to structure-specific DNA binding | ERCC1 |
| contributes_to endodeoxyribonuclease activity | RAD51L3,DMC1,RAD51,RAD51D,XRCC2,RAD51L1,RAD51B |
Interacting Protein
ERCC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC4.
SLX4;SLX1A;ERCC1
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