EPM2A

  • Official Full Name

    epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
  • Overview

    This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants.
  • Synonyms

    EPM2A;epilepsy, progressive myoclonus type 2A, Lafora disease (laforin);epilepsy, progressive myoclonus type 2, Lafora disease (laforin);laforin;LD;LDE;LAFPTPase;lafora PTPase;EPM2;MELF

Recombinant Proteins

  • Chicken
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
EPM2A-2748C Recombinant Chicken EPM2A Mammalian Cells Chicken His
EPM2A-3411H Recombinant Human EPM2A Protein, GST-tagged Wheat Germ Human GST
EPM2A-5255M Recombinant Mouse EPM2A Protein Mammalian Cells Mouse His
EPM2A-568HCL Recombinant Human EPM2A cell lysate Human Non
EPM2A-2821M Recombinant Mouse EPM2A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
EPM2A-2821M-B Recombinant Mouse EPM2A Protein Pre-coupled Magnetic Beads HEK293 Mouse
EPM2A-4388HF Recombinant Full Length Human EPM2A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 331 amino acids

    Involved Pathway

    EPM2A involved in several pathways and played different roles in them. We selected most pathways EPM2A participated on our site, such as Disease,Diseases of carbohydrate metabolism,Diseases of metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease TLR6,ANTXR2,CCNC,ACAN,CDC37,NA,KPNA5,VPS37A,DOCK2,SFTPB
    Metabolism KHK,NDOR1,CA5B,MED15,ARSK,MAPK1IP1L,SACM1L,C20orf7,PLB1,CPOX
    Diseases of carbohydrate metabolism GYG2,GYG1
    Diseases of metabolism CCDC59,GYG1,CYP11A1,MMADHC,FDX1,GYG2,MMAA,AMN,FDX1L,SFTPC
    Glycogen synthesis NHLRC1,GYG1A,GYG1B
    Glucose metabolism GYG1A,SLC25A10,GYG1B,AGL,SLC25A13,SLC25A1A,GYG2,SLC25A1,SLC25A11,PYGMB
    Metabolism of carbohydrates STAB2,MAPK1IP1L,HAS1,LYVE1,SLC25A1,DSEL,SLC26A2,PFKLB,NHLRC1,Gpc2

    Protein Function

    EPM2A has several biochemical functions, for example, carbohydrate phosphatase activity,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPM2A itself. We selected most functions EPM2A had, and list some proteins which have the same functions with EPM2A. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine phosphatase activity CDC14AA,PPM1LA,PPP5C,PPM1G,PPM1F,MTMR6,PPEF1,MTMR3,PPP1R3D,TAB1
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity INPP5B,PTPMT1,OCRL,INPP5E,SYNJ2
    protein tyrosine phosphatase activity PTPRK,DUSP3,DUSP23A,EYA1,PTPN1,PTPREB,DUSP2,DUSP3B,PTPN23A,SSH2B
    starch binding GPCPD1,STBD1
    protein binding TIMP1,PIM3,BID,DIS3L2,CRHR1,NTSR1,PPM1K,BUB3,CREB3L3,AXL
    protein tyrosine/serine/threonine phosphatase activity PTENB,DUSP16,DUSP4,PTPDC1,CTDSPL2A,DUSP19B,PXYLP1,CDC14AB,SSH1,SSH3

    Interacting Protein

    EPM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of EPM2A.

    RPL10

    Resources

    References

    Ask a Question for All EPM2A Products

    Required fields are marked with *

    My Review for All EPM2A Products

    Required fields are marked with *