EPHX2
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Official Full Name
epoxide hydrolase 2, cytoplasmic -
Overview
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
EPHX2;epoxide hydrolase 2, cytoplasmic;epoxide hydrolase 2;epoxide hydratase;epoxide hydrolase, soluble;epoxide hydrolase 2, cytosolic;CEH;SEH
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
- SUMO
Involved Pathway
EPHX2 involved in several pathways and played different roles in them. We selected most pathways EPHX2 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ACSL3B,GSTK1,HAO1,HMGCLL1,NOS2,ACSL4,HSD17B4,PEX2,AGXTA,ABCD2 |
| Arachidonic acid metabolism | CYP2B19,FAAH2B,LTC4S,PLA2G2E,GGTLC1,CBR1L,PTGR1,CYP2C8,CYP2P9,ALOX8 |
| Metabolic pathways | HMGCL,CYP2C8,NTPCR,CYP2C39,ITPKC,EXTL3,LIAS,SGPL1,NME2A,DGKE |
Protein Function
EPHX2 has several biochemical functions, for example, 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity,epoxide hydrolase activity,lipid phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHX2 itself. We selected most functions EPHX2 had, and list some proteins which have the same functions with EPHX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid phosphatase activity | PPAP2CB,INPP5K,PPAP2C,LPPR1,LPPR3,LPPR5A,PPAP2D,PPAP2A,PTENA,PTENB |
| epoxide hydrolase activity | EPHX1,EPHX3,LTA4H,RNPEP,EPHX4,Npepo |
| magnesium ion binding | RPS6KA3,PKLR,ATP8B3,ENOPH1,MARK2,NME1,FOXK2,IDH1,FDXACB1,PPA2 |
| toxic substance binding | NEFH,Alb,H2-AB1,PHAX,ASS1,A4GALT,CHRNA7,DSG1,GUCY2C,AZU1 |
| phosphatase activity | CTDNEP1B,C12orf5,PPP1CB,PTPRDB,CTDSPL2B,DUSP3B,PPP1CC,PTPN22,CA3,DUSP19A |
| protein homodimerization activity | ROPN1B,LCN2,GRHPR,VPS4B,PVRL4,HPGD,ANG,SMAGP,BMP4,HES1 |
| receptor binding | IDH1,CXADR,SMARCD3,CDH5,CRAT,HACL1,SEMA4D,RAB8B,GSDMA2,TNFSF14 |
Interacting Protein
EPHX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHX2.
TERF1;MVP;papC;NIPSNAP3A
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References
- Ma, WJ; Sun, YH; et al. Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 94:13-19(2015).
- Lindh, M; Svensson, F; et al. Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data. JOURNAL OF CHEMICAL INFORMATION AND MODELING 55:343-353(2015).
