EP400
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Official Full Name
E1A binding protein p400 -
Overview
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. -
Synonyms
EP400;E1A binding protein p400;Rabbit;Human;Rabbit Anti-Human EP400 Polyclonal Antibody;Rabbit Anti-Human EP400;Polyclonal Antibody;Rabbit Anti-Human EP400 Antibody;Polyclonal;Rabbit Anti-Human EP400 Polyclonal;Antibody;Rabbit Anti-Human E1A binding protein p400 Antibody;Rabbit Anti-Human E1A binding protein p400 Polyclonal;Anti-Human EP400 Antibody;Anti-Human EP400 Polyclonal;Anti-Human E1A binding protein p400 Antibody;Anti-Human E1A binding protein p400 Polyclonal;Anti-Human EP400;Anti-EP400;Anti-Human E1A binding protein p400;Anti-E1A binding protein p400
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EP400-2361C | Recombinant Chicken EP400 | Mammalian Cells | Chicken | His |
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| EP400-3347H | Recombinant Human EP400 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EP400-559HCL | Recombinant Human EP400 cell lysate | Human | Non |
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Involved Pathway
EP400 involved in several pathways and played different roles in them. We selected most pathways EP400 participated on our site, such as Cellular Senescence,Cellular responses to stress,Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP400 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | SAP30L,VPS72,MSL2,SMARCC2,KDM4B,KAT7A,SMYD3,CHD4,WDR77,MBIP |
| DNA Damage/Telomere Stress Induced Senescence | HIRA,RAD50,CABIN1,POT1,TERF2,HIST1H1A,UBN1,POT1A,H1F0,TERF1 |
| HATs acetylate histones | ZZZ3,EPC1,ING3,TADA2B,ELP2,DR1,ATXN7L3,ING5B,USP22,MSL3 |
| Chromatin modifying enzymes | SMARCC2,ATXN7,PAX3A,SUDS3,ACTL6B,PADI3,ING5,ATXN7L3,KANSL3,TADA2B |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | HMGA1-RS1,HIRA,HIST1H1A,HIST1H1D,HIST1H1C,ASF1A,H1F0,CABIN1,UBN1,HIST1H1E |
| Cellular responses to stress | BMI1A,CDKN2C,CBX4,EED,CDKN2D,MAPKAPK2B,CBX8B,ATG101,RB1CC1,HSPH1 |
| Cellular Senescence | CBX6,Txn1,HIST1H1A,ASF1A,HIST3H2BB,PHC2,AGO1,HTATIP,CDKN2C,EED |
Protein Function
EP400 has several biochemical functions, for example, ATP binding,DNA binding,helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EP400 itself. We selected most functions EP400 had, and list some proteins which have the same functions with EP400. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | INCENP,OBFC1,HINFP,TA,NRBP1,PLD3,FASLG,MOS,NRP1,MSH6 |
| DNA binding | TRIM21,UBP1,ZNF518A,MLL1,FOXO3A,ZNF410,HMGB4,PPARA,MSGN1,NKX2-6 |
| helicase activity | DHX58,RAD54L,DHX33,CHD7,DDX52,WRN,MOV10,ACTG2,CHD9,TDRD12 |
| ATP binding | ACTC1B,SRPK1A,CHUK,CDKL1,PTK2BB,TPK1,MTHFD1,NRK,DARS,IRAK3 |
Interacting Protein
EP400 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP400 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP400.
ALAS1;MYC;Dlg4;ACTL6A;FOS;PARP1;BRD8;RUVBL2;TBC1D4;ESR1;MRGBP;DYRK1B
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