ELP3
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Official Full Name
elongation protein 3 homolog -
Overview
ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript;elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 (PubMed 19185337)). -
Synonyms
ELP3;elongation protein 3 homolog (S. cerevisiae);elongator complex protein 3;FLJ10422;KAT9;hELP3
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
ELP3 involved in several pathways and played different roles in them. We selected most pathways ELP3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | SMARCC1B,JADE1,KDM2A,MSL2B,KDM5B,KDM1A,KDM4B,ING5B,SUZ12B,PBRM1L |
| HATs acetylate histones | YEATS4,ANO9A,KAT7B,VPS72,ACTL6A,MSL2B,KAT7,TADA2A,EP400,TADA1 |
| Chromatin modifying enzymes | KAT7,PHF2,MSL1,RBBP5,SMARCA4,BRD8,SETD3,MCRS1,ACTL6A,TADA2A |
Protein Function
ELP3 has several biochemical functions, for example, H3 histone acetyltransferase activity,H4 histone acetyltransferase activity,contributes_to RNA polymerase II core binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELP3 itself. We selected most functions ELP3 had, and list some proteins which have the same functions with ELP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ATP1A3A,SOD3A,ZFP609,EXO5,PPP2CA,ZNF454,SALL1A,RFNG,XIRP2,KLF10 |
| contributes_to RNA polymerase II core binding | IKBKAP,ELP4,ELP2 |
| H4 histone acetyltransferase activity | BRCA2,NAA50,NAT15,HAT1,NAA60 |
| phosphorylase kinase regulator activity | IKBKAP,PRKAG2,ELP4 |
| protein binding | SAP30,PDCL3,EDDM3B,LBX1,STATH,ETV5,KL,KIF2A,SEPT3,SGPL1 |
| H3 histone acetyltransferase activity | KAT2A,BRCA2 |
| iron-sulfur cluster binding | AOX4,FXN,NFS1,RSAD1,NUBP1,ABAT,CISD3,ISCUB,FDX1B,PRIM2 |
Interacting Protein
ELP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELP3.
IKBKAP;POLR2A;NFKBIA;ELP5;ELP4
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References
- Gu, JX; Sun, DM; et al. Human Elongator complex is involved in cell cycle and suppresses cell growth in 293T human embryonic kidney cells. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41:831-838(2009).
- Barton, D; Braet, F; et al. ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells. NEUROSCIENCE LETTERS 455:60-64(2009).
- Klassen, R; Meinhardt, F; et al. Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora. MOLECULAR GENETICS AND GENOMICS 270:190-199(2003).
