ELOVL6
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Official Full Name
ELOVL fatty acid elongase 6 -
Overview
Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008] -
Synonyms
ELOVL6;ELOVL fatty acid elongase 6;FAE;LCE;FACE;elongation of very long chain fatty acids protein 6;hELO2;ELOVL FA elongase 6;fatty acid elongase 2;fatty acyl-CoA elongase;long-chain fatty-acyl elongase;3-keto acyl-CoA synthase ELOVL6;very-long-chain 3-oxoacyl-CoA synthase 6;ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- zebrafish
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- His&Fc&Avi
Involved Pathway
ELOVL6 involved in several pathways and played different roles in them. We selected most pathways ELOVL6 participated on our site, such as Fatty acid elongation,Biosynthesis of unsaturated fatty acids,Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELOVL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid metabolism | ACADL,HSD17B12,ACSL3A,CPT1A,MECR,ACSBG1,ACSL4,ACSL1B,ACSL3,ACAA1A |
| Biosynthesis of unsaturated fatty acids | ACOX1,HADHAB,HADHAA,FADS2,ACOX3,ACAA1,SCDB,ACOT2,PTPLAD2,ELOVL5 |
| Fatty acid elongation | ACOT2,PTPLAD1,HADHAA,TECRB,ELOVL4,ACOT5,HSD17B12A,HADH,ACOT7,ACOT1 |
Protein Function
ELOVL6 has several biochemical functions, for example, protein binding,transferase activity, transferring acyl groups other than amino-acyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by ELOVL6 itself. We selected most functions ELOVL6 had, and list some proteins which have the same functions with ELOVL6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IL24,DCUN1D5,TIMELESS,IREB2,WFS1,SPIN1,MARCH10,GRB2,AKAP7,TTF2 |
| transferase activity, transferring acyl groups other than amino-acyl groups | ACAA1A,KAT7B,MOGAT3A,DGAT2L6,KAT6A,SCP2A,KAT7A,HTATIP |
Interacting Protein
ELOVL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELOVL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELOVL6.
Resources
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References
- Yamada, K; Mizukoshi, E; et al. Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. LIVER INTERNATIONAL 35:582-590(2015).
- Moon, YA; Ochoa, CR; et al. Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance. JOURNAL OF LIPID RESEARCH 55:2597-2605(2014).
