ELAVL2

What is ELAVL2 Protein?

ELAVL2 is a protein that might not be a household name, but it plays a significant part in how our nervous system functions. This protein belongs to a family known for binding to RNA, which is crucial in controlling how genetic information is turned into proteins. Think of it as a sort of manager, making sure everything runs smoothly in the production line of our cells. ELAVL2 is particularly important in the brain, where it helps regulate the stability and translation of mRNAs, which in turn can affect everything from neuron growth to cognitive functions. Researchers are delving into understanding its precise roles, as disruptions in its function could be linked to various neurological disorders. It's like a backstage hero ensuring our brain's activities are in sync, and scientists are keen on exploring its potential as a target for treating brain-related issues.

What is the Function of ELAVL2 Protein?

ELAVL2 acts like a backstage manager in the brain, dealing with RNA, which is essential for making proteins from genetic instructions. It ensures the right proteins are produced exactly when needed, which is key for neuron growth and communication. By interacting with RNA, ELAVL2 impacts the stability and conversion of these molecules into proteins, affecting brain functions like memory and thinking. Researchers are curious about it because problems with ELAVL2 might be linked to brain disorders. Basically, ELAVL2 keeps things running smoothly in the brain, ensuring everything is in sync.

ELAVL2 Related Signaling Pathway

The ELAVL2-related signaling pathway is like a finely tuned network inside our brain cells, where ELAVL2 plays an essential role. This pathway involves ELAVL2 interacting with RNA molecules, helping to stabilize them and controlling how they're converted into proteins. It's a bit like quality control, ensuring that neurons get exactly what they need to function well. This process is crucial for brain activities, including memory retention and learning. If the pathway goes off track, it might lead to issues with neuron communication and could even be a factor in some neurological disorders. Scientists are diving into this pathway to understand how it can affect brain health and explore potential treatments for brain-related issues. ELAVL2's involvement in this pathway showcases its importance in keeping our brain cells firing on all cylinders.

ELAVL2 Related Diseases

ELAVL2 is linked to a few brain-related disorders, making it a hot topic among researchers. When ELAVL2 isn't doing its job right, it can mess with how brain cells communicate because it affects RNA stability and protein production. This disruption can lead to problems like cognitive decline or developmental delays. Some studies suggest a connection between faulty ELAVL2 activity and conditions like autism or even neurodegenerative diseases like Alzheimer's. Since ELAVL2 helps keep neurons functioning properly, any hiccups in its activity can have noticeable effects on brain health. Scientists are keen to unlock more about how ELAVL2 influences these diseases, hoping to find targeted therapies that could correct these issues and improve outcomes for people affected by such conditions.

Bioapplications of ELAVL2

When diving into the role of ELAVL2, also known as Hu antigen B, it's clear that this protein is pretty important in the world of biology applications. ELAVL2 is part of a family of proteins that manage how genes get expressed after transcription by binding to RNA and stabilizing certain mRNAs. This role is super crucial when thinking about nerve cells and how they grow or react to things like stress. Because of this, ELAVL2 finds its spotlight in brain-related studies and might hold some answers to conditions like neurodevelopmental disorders or diseases that break down neurons over time. Besides its impact on the brain, researchers are also looking at this protein as a potential cancer biomarker. This is due to its knack for interacting with mRNAs tied to cancer progression. Overall, whether it’s about healthy brain functions or finding new angles in cancer research, ELAVL2 seems to have some valuable insights to offer.

Case Study 1: Liu Q. et al. Cell Death Dis. 2025

Research on neural tube defects (NTDs) shows that low levels of apolipoprotein M (ApoM) are found in affected spinal cords. This deficiency disturbs cellular function, as it affects Elavl2 and Nnt mRNA, leading to cell damage and contributing to NTDs. Zic3 helps boost ApoM production, and delivering Zic3 or ApoM can improve cell health in NTD cases. These insights underscore the importance of the Zic3-ApoM pathway in neural development and suggest new therapy targets for NTDs.

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  Fig1. The endogenous interactions between ApoM and Elavl2 were examined by Co-IP.
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  Fig2. RNA pull-down analysis determined the enrichment of Elavl2 by biotin-labelled Nnt.

Case Study 2: Kim Y. et al. NPJ Precis Oncol. 2024

Glioblastoma (GBM), the deadliest brain cancer, is hard to treat due to its complex nature. This study focused on ELAVL2, an RNA-binding protein, often lacking in GBM. Its absence makes cancer cells more aggressive and treatment-resistant. Patients with higher ELAVL2 levels tend to have better survival rates. ELAVL2 stabilizes molecules that suppress cancer's aggressive behavior, highlighting its potential as a therapy target for GBM.

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  Fig3. Immunoblotting in GBM28 transfected with vector control (vtr) or overexpression vector.
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  Fig4. Immunoblotting of ELAVL2 which was pulled down by a SH3GL3 or DNM3 sense RNA probe.

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  Fig1. DHA inhibits the proliferation and migration of PASMCs through the ELAVL2/miR-503/PI3K/AKT axis. (Haijian Cai, 2022)
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  Fig2. Diagram of proposed functions and mechanisms of ELAVL2. (Chao Yang, 2021)

ELAVL2 has several biochemical functions, for example, mRNA 3-UTR binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAVL2 itself. We selected most functions ELAVL2 had, and list some proteins which have the same functions with ELAVL2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	MAPK8IP3,HNRNPC,VASP,ZFP346,LILRB3,COASY,KCNE2,BDKRB1,HNRNPA1,ASB2
poly(A) RNA binding	ZFP207,TBCA,MYBBP1A,CAPRIN1,CISD2,LARP7,MRPS30,RPL13A,RPS2,TRMT1
mRNA 3-UTR binding	IGF2BP3,ZNF385A,YBX2,RNF40,PARN,RBMS3,CPEB1,CIRBP,RBM38,ELAVL1
nucleotide binding	IGF1RA,ATP8B3,ELAVL1,LARP7,CPS1,MXE,HNRNPL2,GRK1A,POLD1,SRSF6B

ELAVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAVL2.