EIF2S3
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Official Full Name
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -
Overview
The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010] -
Synonyms
EIF2S3;eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa;EIF2;EIF2G;eIF-2gA;EIF2gamma;eukaryotic translation initiation factor 2 subunit 3;eIF-2gX;eIF-2-gamma X;eukaryotic translation initiation factor 2G;eukaryotic translation initiation factor 2 subunit gamma X
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EIF2S3-11986Z | Recombinant Zebrafish EIF2S3 | Mammalian Cells | Zebrafish | His |
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| EIF2S3-1407C | Recombinant Chicken EIF2S3 | Mammalian Cells | Chicken | His |
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| EIF2S3-28379TH | Recombinant Human EIF2S3 | Wheat Germ | Human | Non | 90 amino acids |
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| EIF2S3-3175H | Recombinant Human EIF2S3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EIF2S3-4198HF | Recombinant Full Length Human EIF2S3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 472 amino acids |
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Involved Pathway
EIF2S3 involved in several pathways and played different roles in them. We selected most pathways EIF2S3 participated on our site, such as ABC-family proteins mediated transport,Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4A1,EIF4E,EIF1AXA,EIF4H,EIF4EB,EIF4G1,FAUB,EIF2S1A,EIF4EBP1,EIF1AX |
| Formation of the ternary complex, and subsequently, the 43S complex | EIF1AXA,EIF1AX,EIF2S1,EIF2S1A,FAUB,EIF3K |
| Gene Expression | UBTF,MED26,CCDC76,ZNF212,ANP32A,SNRNP25,GATAD2B,POLRMT,ADARB1,TRIM33 |
| Cap-dependent Translation Initiation | EIF4B,EIF4EBP1,EIF5,EIF4H,EIF2S1,EIF1AX,FAUB,EIF2B1,EIF4EB,RPL35 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | FAUB,EIF1AXA,EIF4A2,EIF4B,EIF4A1,EIF4H,EIF5,EIF3K,EIF2S1,RPL35 |
| Eukaryotic Translation Initiation | EIF2S1A,EIF2B1,EIF1AXA,FAUB,EIF4A2,EIF4A1,EIF1AX,EIF4H,EIF4EB,EIF4B |
| ABC-family proteins mediated transport | CFTR,ABCD3B,ABCA4A,ABCA7,ABCG4B,ABCC2,EIF2S1A,ABCF1,EIF2S1,ABCA8 |
| L13a-mediated translational silencing of Ceruloplasmin expression | EIF4H,EIF1AX,FAUB,EIF3K,EIF1AXA,EIF2S1A |
Protein Function
EIF2S3 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S3 itself. We selected most functions EIF2S3 had, and list some proteins which have the same functions with EIF2S3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| translation factor activity, RNA binding | CPEB3,EIF4H,EIF4G2,CPEB1,SOX11,EIF4A1,EIF1,EEF2K,EIF1AX,GTF2H2 |
| translation initiation factor activity | EIF1AX,EIF3J,EIF2D,EIF1AD,EIF2S1,EIF3S6IP,EIF5,EIF3HB,EIF4E,EIF2S2 |
| protein binding | KLKB1,ALK,MAP2,ZWINT,TLDC2,NR0B1,CRTC2,MSMB,RAD9A,ABI3 |
| GTPase activity | RABL2B,MXA,RALBA,RHOT1,GNA12,GNAO1B,TRIM23,RAB1BA,RAB5B,GNG3 |
| GTP binding | OLA1,DNM3,RNF112,RAP1AB,GNA11B,ARL5A,RAB42B,RALBB,RNGTT,GUCY2C |
Interacting Protein
EIF2S3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S3.
EIF2S1;EIF2S2;EIF1B;GH1;HLA-B;CASP4;IKBKE;NDRG1;PRKAB1;TRAF6;yopM;ychF;ssrna_ug
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References
- Chang, YT; Yao, CT; et al. Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets. WORLD JOURNAL OF GASTROENTEROLOGY 20:17476-17482(2014).
- Chang, YT; Huang, CS; et al. Gene expression profile of peripheral blood in colorectal cancer. WORLD JOURNAL OF GASTROENTEROLOGY 20:14463-14471(2014).
