EHD1
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Official Full Name
EH-domain containing 1 -
Overview
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] -
Synonyms
EHD1;EH-domain containing 1;PAST;PAST1;H-PAST;HPAST1;EH domain-containing protein 1;testilin;PAST homolog 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EHD1 involved in several pathways and played different roles in them. We selected most pathways EHD1 participated on our site, such as Endocytosis,Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ARFGEF2,ARF6A,SH3GL3B,HLA-B,KITB,TFR1A,PIP5K1AA,CBLB,GIT2,CHMP4C |
| Hemostasis | APOA1B,NFE2,KIF5A,IRF2A,JAM2B,CABLES1,PRKCHB,RHOGA,BRPF3,GATA5 |
| Insulin Signaling | GRB10,MAPK6,STXBP4,RHOJ,MAP3K10,MAP4K5,MYO1C,CAP1,KIF5B,RRAD |
| Factors involved in megakaryocyte development and platelet production | LRRC16A,HBG2,AKAP1B,KIF5B,BA2,H3F3B.1,KIFAP3,DOCK6,KIFC1,GATA1A |
Protein Function
EHD1 has several biochemical functions, for example, ATP binding,GTP binding,Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EHD1 itself. We selected most functions EHD1 had, and list some proteins which have the same functions with EHD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAB3DA,SRP54A,RASD2,SEPT4A,RHOGD,RND3,GNAO1B,RAP1AA,RHOG,RAB3AA |
| protein binding | KIF14,BNIPL,CTNNB2,HLCS,MYBPH,GP9,CCDC112,RNASE1,NARG1,POP7 |
| ATP binding | RECQL,KIF1B,DNAHC8,NEK11,KIF11,TOR2A,UBA5,ABL1,WEE1,SEPHS1 |
| calcium ion binding | SPOCK3,SYTL3,TNNC1,CABP1,CPNE6,PCDH1G9,CETN3,PITPNM3,S100A6,ABP1 |
| Rab GTPase binding | LLGL1,ULK1,SYTL3,SYTL4,RAB11FIP4B,KIF16B,MICALL2,RAB11FIP1,ZFP652,RAB11FIP5 |
Interacting Protein
EHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EHD1.
ANKFY1;STON2;ANKFY1;MICALL1;Snap29;HSPB1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;PAPD5;RAB11A;SNW1;CDC5L
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References
- Jakobsson, J; Ackermann, F; et al. Regulation of Synaptic Vesicle Budding and Dynamin Function by an EHD ATPase. JOURNAL OF NEUROSCIENCE 31:13972-13980(2011).
- Hadwiger, G; Dour, S; et al. A Monoclonal Antibody Toolkit for C. elegans. PLOS ONE 5:-(2010).
