EEF1A2
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Official Full Name
eukaryotic translation elongation factor 1 alpha 2 -
Overview
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014] -
Synonyms
EEF1A2;eukaryotic translation elongation factor 1 alpha 2;HS1;STN;EF1A;STNL;EEF1AL;EF-1-alpha-2;elongation factor 1-alpha 2;statin-S1;eukaryotic elongation factor 1 A-2
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EEF1A2-12289H | Recombinant Human EEF1A2 protein, GST-tagged | E.coli | Human | GST | 109-463 aa | |
| EEF1A2-2014R | Recombinant Rat EEF1A2 Protein | Mammalian Cells | Rat | His |
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| EEF1A2-3061H | Recombinant Human EEF1A2, T7-tagged | E.coli | Human | T7 | 1-463 a.a. |
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| EEF1A2-3067H | Recombinant Human EEF1A2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| EEF1A2-3258C | Recombinant Chicken EEF1A2 | Mammalian Cells | Chicken | His |
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| EEF1A2-4999M | Recombinant Mouse EEF1A2 Protein | Mammalian Cells | Mouse | His |
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| EEF1A2-515Z | Recombinant Zebrafish EEF1A2 | Mammalian Cells | Zebrafish | His |
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| EEF1A2-242HCL | Recombinant Human EEF1A2 lysate | HEK293 | Human | Non |
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| EEF1A2-12290H | Recombinant Human EEF1A2 protein, His-tagged | E.coli | Human | His | Gly213~Lys463 |
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| EEF1A2-1671R | Recombinant Rat EEF1A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| EEF1A2-1671R-B | Recombinant Rat EEF1A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| EEF1A2-2646M | Recombinant Mouse EEF1A2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| EEF1A2-2646M-B | Recombinant Mouse EEF1A2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EEF1A2-4206HF | Recombinant Full Length Human EEF1A2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 463 amino acids |
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Involved Pathway
EEF1A2 involved in several pathways and played different roles in them. We selected most pathways EEF1A2 participated on our site, such as Eukaryotic Translation Elongation,Gene Expression,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEF1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Translation | EEF1G,APEH,EIF5,EEF1B2,EIF2B1,EEF1D |
| Gene Expression | METTL3,ZNF480,EIF1AXA,ZNF18,SAP30,TRMT61A,MYBL1,ZNF136,ZNF10,RNF111 |
| Translation Factors | EEF1B2,PAIP1,EIF5A,EEF2B,EEF1D,EIF4EBP2,EIF2B1,EEF1G,EIF1 |
| Metabolism of proteins | LTF,IGFBP6A,CTAGE5,EXOC8,COX17,SFTPC,INHBAA,INHA,TRAPPC3,CBX4 |
| Legionellosis | HSF1,NAIP1,NFKB1,NAIP7,ITGB2,SAR1A,HSPD1,TLR4,ITGB2L,HBS1L |
| RNA transport | GEMIN8,ALYREF,NUP210,MAGOH2,EIF3EA,PEAK1,THOC7,PABPC1A,EIF3EB,RPP14 |
| Eukaryotic Translation Elongation | EEF1A1,RPL35,EEF1D,EEF2,EEF1B2,EEF1G |
Protein Function
EEF1A2 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EEF1A2 itself. We selected most functions EEF1A2 had, and list some proteins which have the same functions with EEF1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | GTPBP4,RAB3AB,GNGT1,MRAS,RAB15,GBP2,TUBB5,RRAGCA,RAB7L1,ARF1 |
| protein binding | TMEM174,SVIL,RAB2A,IL1A,ZFP110,TTC9C,IGFL1,RPL15,CXCL11,EXOC3L |
| translation elongation factor activity | EFTUD1,EEF1A1B,EEF1A1L2,EEF1E1,EEF1B2,EEF2B,EEF1G,GFM1,EEF1A1,TUFM |
| protein kinase binding | JTB,DLG1L,CLTC,NSF,CDKN2B,IL12RB2,PRKCZ,AXIN1,CALM1,GHR |
| GTP binding | GNAI2,DIRAS1B,AGAP2,RAB35B,MRAS,RHOA,RAB30,PCK2,GNAQ,ARFRP1 |
| translation factor activity, RNA binding | EEF1D,CPEB1B,EIF5,GTF2H2,EIF4A1,GTF2H3,EIF4H,EIF4G1,EIF4G3,CPEB2 |
Interacting Protein
EEF1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEF1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EEF1A2.
ABTB1;NFKB2;CHUK;TNFRSF1B;EEF1B2;VARS;EEF1D;MAP3K8;NFKB2;RELA;TRAF2;MAP3K1;TRADD;LRRK2;MAP3K3;TAB2;TRAF6;RIPK3
Resources
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References
- Chen, CY; Fang, HY; et al. Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells. CANCER SCIENCE 102:1582-1589(2011).
- Piazzi, M; Bavelloni, A; et al. eEF1A Phosphorylation in the Nucleus of Insulin-stimulated C2C12 Myoblasts SER53 IS A NOVEL SUBSTRATE FOR PROTEIN KINASE C beta I. MOLECULAR & CELLULAR PROTEOMICS 9:-(2010).
