ECI2
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Official Full Name
enoyl-CoA delta isomerase 2 -
Overview
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. -
Synonyms
ECI2;enoyl-CoA delta isomerase 2;PECI, peroxisomal D3,D2 enoyl CoA isomerase;enoyl-CoA delta isomerase 2, mitochondrial;Hepatocellular carcinoma associated antigen 88;ACBD2;acyl Coenzyme A binding domain containing 2;DRS1;HCA88;DBI-related prote
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ECI2 involved in several pathways and played different roles in them. We selected most pathways ECI2 participated on our site, such as Fatty acid degradation,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid degradation | ACSL3A,ADH1,ECI1,ACSL4A,ACOX3,CPT2,ACSBG2,HADHA,ACSL3,HADHAA |
| Peroxisome | PEX1,ABCD2,DAO.1,PIPOX,SCP2A,CAT,ACOX1,HMGCL,CRATA,IDH1 |
Protein Function
ECI2 has several biochemical functions, for example, catalytic activity,dodecenoyl-CoA delta-isomerase activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ECI2 itself. We selected most functions ECI2 had, and list some proteins which have the same functions with ECI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | GRP,HLA-F,PGR,FGF12A,GFRA1,DAO,TMEM38A,PVRL1,ICOSLG,TIGIT |
| catalytic activity | APOBEC2A,RAG1,MOGS,DIP2B,HHIPL1,PNP4A,SYN2B,LYZ1,LANCL1,ALDOCB |
| isomerase activity | HMGCS1,TPI1B,ITPK1,PPIFA,PDIA5,PTGESL,PPIAB,FKBP1AA,GPI1,PPIFB |
| fatty-acyl-CoA binding | HMGCL,PECI,ACADSB,ACBD5B,ACADL,ACBD5A,ACOX2,ACBD3,GCDH,GCDHA |
| dodecenoyl-CoA delta-isomerase activity | PECI,EHHADH,ECI1 |
Interacting Protein
ECI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECI2.
Hmga2;Grid2
Resources
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References
- Filppula, SA; Yagi, AI; et al. Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase from rat liver - Molecular characterization. JOURNAL OF BIOLOGICAL CHEMISTRY 273:349-355(1998).
- DieuaideNoubhani, M; Novikov, D; et al. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver - Relationship between the different dehydrogenases and evidence that fatty acids and the C-27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins. EUROPEAN JOURNAL OF BIOCHEMISTRY 240:660-666(1996).
