ECI1
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Official Full Name
enoyl-CoA delta isomerase 1 -
Overview
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. -
Synonyms
ECI1;enoyl-CoA delta isomerase 1;DCI, dodecenoyl CoA isomerase , dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase);enoyl-CoA delta isomerase 1, mitochondrial;3;2 trans enoyl CoA isomerase;3,2 trans enoyl Coenzyme A isomerase;Acetylene allene isomerase;D3,D2 enoyl CoA isomerase;DCI protein;Delta(3),Delta(2) enoyl CoA isomerase;Delta3, delta2 enoyl CoA isomerase;Dodecenoyl CoA delta Isomerase;Dodecenoyl CoA isomerase;Dodecenoyl Coenzyme A delta isomerase;Dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase);Dodecenoyl Coenzyme A delta isomerase 3,2 trans enoyl Coenzyme A isomerase, isoform CRA a;OTTHUMP00000159049;dodecenoyl-CoA isomerase;D3,D2-enoyl-CoA isomerase;acetylene-allene isomerase;3,2 trans-enoyl-CoA isomerase;delta3, delta2-enoyl-CoA isomerase;3,2 trans-enoyl-Coenzyme A isomerase;delta(3),Delta(2)-enoyl-CoA isomerase;3,2-trans-enoyl-CoA isomerase, mitochondrial;dodecenoyl-CoA delta isomerase (3,2 trans-enoyl-CoA isomerase);dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase);DCI
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ECI1-2445H | Recombinant human ECI1, His-tagged | E.coli | Human | His |
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| ECI1-298H | Recombinant Human ECI1 Protein, His-tagged | E.coli | Human | His |
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| ECI1-4968C | Recombinant Chicken ECI1 | Mammalian Cells | Chicken | His |
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| ECI1-4970M | Recombinant Mouse ECI1 Protein | Mammalian Cells | Mouse | His |
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| ECI1-5131H | Recombinant Human ECI1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ECI1-445HCL | Recombinant Human ECI1 cell lysate | Human | Non |
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| ECI1-1398H | Recombinant Human ECI1 Protein, His-tagged | E.coli | Human | His | Ala158-Gly302 |
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| Eci1-1399R | Recombinant Rat Eci1 Protein, His-tagged | E.coli | Rat | His | Phe29-Gly289 |
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| Eci1-1400M | Recombinant Mouse Eci1 Protein, His-tagged | E.coli | Mouse | His | Phe29-Gly289 |
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| ECI1-2626M | Recombinant Mouse ECI1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ECI1-2626M-B | Recombinant Mouse ECI1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ECI1-3751HF | Recombinant Full Length Human ECI1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 243 amino acids |
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Involved Pathway
ECI1 involved in several pathways and played different roles in them. We selected most pathways ECI1 participated on our site, such as Fatty Acid Beta Oxidation,Fatty acid degradation,Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial Fatty Acid Beta-Oxidation | DECR1,ACAD11 |
| Mitochondrial LC-Fatty Acid Beta-Oxidation | SLC25A20,EHHADH,CPT2 |
| Metabolism of lipids and lipoproteins | MED18,CLPS,PPARGC1B,FABP9,INSIG1,ACOT11A,MED10,FABP12,ANKRD1,FABP11A |
| Fatty acid, triacylglycerol, and ketone body metabolism | TIAM2,MED25,Agmo,GRHL1,YAP1,G0S2,ACOT7,MED23,ACOT9.2,CPT2 |
| Metabolism | COX4I1,VAPB,SUMF2,CIAO1,PDK2B,ACOT2,SLC2A3,ADK,COX6B1,CYGB1 |
| Fatty Acid Beta Oxidation | CRAT,DECR1,CPT2,CPT1A,SLC25A20,CPT1B,CHKB |
| Fatty acid degradation | ADH7,HADH,GCDHA,ACSL4B,ECI2,CPT1B,HADHA,HADHAB,ACSBG1,ACADM |
Protein Function
ECI1 has several biochemical functions, for example, dodecenoyl-CoA delta-isomerase activity,identical protein binding,intramolecular oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECI1 itself. We selected most functions ECI1 had, and list some proteins which have the same functions with ECI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | STXBP1,PTPRM,CLDN14,VWA2,FRS3,APP,IAPP,ATXN10,EDC3,GOT1 |
| dodecenoyl-CoA delta-isomerase activity | EHHADH,ECI2,PECI |
Interacting Protein
ECI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECI1.
MAPKAP1;POT1;ICT1
Resources
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References
- Filppula, SA; Yagi, AI; et al. Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase from rat liver - Molecular characterization. JOURNAL OF BIOLOGICAL CHEMISTRY 273:349-355(1998).
- DieuaideNoubhani, M; Novikov, D; et al. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver - Relationship between the different dehydrogenases and evidence that fatty acids and the C-27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins. EUROPEAN JOURNAL OF BIOCHEMISTRY 240:660-666(1996).
