E2F8
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Official Full Name
E2F transcription factor 8 -
Overview
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for;progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the;nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been;identified. -
Synonyms
E2F8;E2F transcription factor 8;transcription factor E2F8;FLJ23311;E2F 8;E2F family member 82;E2F-8;E2F8_HUMAN;OTTHUMP00000231893;OTTHUMP00000231894;E2F family member 8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| E2F8-4937M | Recombinant Mouse E2F8 Protein | Mammalian Cell | Mouse | His |
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| E2F8-6740HCL | Recombinant Human E2F8 293 Cell Lysate | HEK293 | Human | Non |
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| E2F8-2601M | Recombinant Mouse E2F8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| E2F8-2601M-B | Recombinant Mouse E2F8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| E2F8-4284H | Recombinant Human E2F8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| E2F8-4962HF | Recombinant Full Length Human E2F8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 431 amino acids |
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Involved Pathway
E2F8 involved in several pathways and played different roles in them. We selected most pathways E2F8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
E2F8 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,core promoter binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F8 itself. We selected most functions E2F8 had, and list some proteins which have the same functions with E2F8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | OLFM4,RASGRP1,PEX11B,NUDT16,GJC3,CSF1,HINT2,CECR1,TPD52L1,UGT1A7 |
| transcription corepressor activity | HOXC6,HIPK2,BATF3,SIRT1,NR0B1,ATF5,SOD3,LDB1,PRMT5,E2F7 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX2,NFAT5,FOSL2,DLX4,ELF1,PER1,NFE2L3,YBX1,NFIB,MEOX2 |
| core promoter binding | SAFB,CLOCK,NOTCH1,INSM1A,PSPC1,INSM1B,NPAS2,E2F1,HDAC2,GTF2B |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | BACH1,NR1D1,SNAI1,MYPOP,REST,SFPI1,KCNIP3,GFI1,SKIL,ZFP90 |
| transcription factor activity, sequence-specific DNA binding | PRRX2,ZNF23,CRX,SUPT4H1,TCF4,EF1,SMAD3B,FOSL1,ZFY2,E2F6 |
| protein binding | ALOX15,RAB18,MAP3K2,SNX4,Apba1,CCBE1,BATF,ORC3L,AZU1,H3F3C |
Interacting Protein
E2F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F8.
TFCP2;FHL3;E2F7;ZDHHC17
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References
- Umemura, S; Shirane, M; et al. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. BRITISH JOURNAL OF CANCER 100:764-771(2009).
- Panchuk, RR; Boiko, NM; et al. Changes in signaling pathways of cell proliferation and apoptosis during NK/Ly lymphoma aging. CELL BIOLOGY INTERNATIONAL 32:1057-1063(2008).
