E2F6
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Official Full Name
E2F transcription factor 6 -
Overview
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. -
Synonyms
E2F6;E2F transcription factor 6;transcription factor E2F6;E2F 6;E2F transcription factor 6, isoform 1;E2F-6;MGC111545
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
E2F6 involved in several pathways and played different roles in them. We selected most pathways E2F6 participated on our site, such as Cell cycle,E2F transcription factor network,G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | NCAPD2,PTTG1,PKMYT1,DPF1,SKA1,CENPW,POT1,TUBGCP2,NPM1,NEDD1 |
| E2F transcription factor network | CES3,DHFR,MYBL2,HBP1,CBX5,RYBP,RBBP8,E2F4,PRMT5,SMARCA2 |
| G1 to S cell cycle control | TFDP1B,MYT1,CDKN1C,ATF6B |
Protein Function
E2F6 has several biochemical functions, for example, DNA binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F6 itself. We selected most functions E2F6 had, and list some proteins which have the same functions with E2F6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | HSBP1,KCNIP3,HOXC6,TMEM38A,TBL1XR1A,FEV,NFIL3,BCL11A,MSC,WNT4 |
| DNA binding | ZFP787,LIG3,BANF2,ESR2,G3BP1,ZNF19,ZNF311,ZBP1,ETV5B,NFIX |
| transcription factor activity, sequence-specific DNA binding | FOXE3,ZFP13,POU2F1B,FOSL1,FOXE1,PAX7,RXRBA,ZNF263,SALL1,ZFP161 |
| protein binding | AGXT,CAP2,P4HB,RPL37A,TRAF2,THEM5,SH2D1B,SERPINA3K,GIPC2,FAM127C |
Interacting Protein
E2F6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F6 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F6.
TFDP2;TFDP1;KRTAP10-7;PIK3R3;Ring1;BMI1
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