E2F4

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  • Overview
  • Review / Q&A

  • Official Full Name

    E2F transcription factor 4, p107/p130-binding

  • Overview

    The E2F family of transcrIPPtion factors regulates gene expression following heterodimerization with the DP family proteins, which promote transition to S phase from G1 phase. E2F activity is controlled by interactions with the retinoblastoma tumor suppre

  • Synonyms

    E2F4;E2F transcription factor 4, p107/p130-binding;transcription factor E2F4;E2F 4;p107/p130-binding protein;E2F-4

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
E2F4-12248H Recombinant Human E2F4 protein, His-tagged E.coli Human His 1-413 aa
E2F4-12603Z Recombinant Zebrafish E2F4 Mammalian Cells Zebrafish His
E2F4-1270C Recombinant Chicken E2F4 Mammalian Cells Chicken His
E2F4-1367R Recombinant Rhesus monkey E2F4 Protein, His-tagged Mammalian Cells Rhesus macaque His
E2F4-3008H Recombinant Human E2F4 Protein, GST-tagged Wheat Germ Human GST
E2F4-4933M Recombinant Mouse E2F4 Protein Mammalian Cells Mouse His
E2F4-6741HCL Recombinant Human E2F4 293 Cell Lysate HEK293 Human Non
E2F4-1192R Recombinant Rhesus Macaque E2F4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
E2F4-1192R-B Recombinant Rhesus Macaque E2F4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
E2F4-2597M Recombinant Mouse E2F4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
E2F4-2597M-B Recombinant Mouse E2F4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
E2F4-4113HF Recombinant Full Length Human E2F4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 413 amino acids
Kit-0318 E2F4 Gene Knockdown Quantification Kit Non

Involved Pathway

E2F4 involved in several pathways and played different roles in them. We selected most pathways E2F4 participated on our site, such as Adipogenesis,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G0 and Early G1 LIN9,TOP2A,DYRK1A,LIN52,PIANP,LIN54,MYBL2,LIN37
Cyclin D associated events in G1 CDKN2B,CDKN2C,CKS1B,PIANP,CDK7,CDKN2D
Cell Cycle, Mitotic CEP135,CEP152,CENPQ,GINS1,PANE1,GOLGA2,WAPAL,CSNK2A1,BLZF1,TUBG2
Adipogenesis SMAD3B,GTF3AA,KLF6A,EGR2B,NAMPT,STIL,BMP3,CEBPA,MBNL1,CEBPD
E2F transcription factor network CES3,RBBP8,HBP1,YY1,CEBPA,PRMT5,E2F6,CBX5,SMARCA2,CES1
G1 Phase PIANP,CKS1B,CDKN2B,CDKN2D,CDKN2C
Cell cycle MAD2L1,WEE1,CCNB3,BORA,FAM175A,HUS1,HDAC6,TUBGCP3,SMAD3A,CETN2

Protein Function

E2F4 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F4 itself. We selected most functions E2F4 had, and list some proteins which have the same functions with E2F4. You can find most of the proteins on our site.

Function Related Protein
protein binding ACTN4,ARAP1,TSPAN6,NR2E3,TTI1,BCL11A,CDC14B,PSMC3,F5,TSC22D3
transcription factor activity, sequence-specific DNA binding PTF1A,MAFA,MYCA,POU3F2B,HOXB5A,CREB5,ZFP641,TBX22,UBN2B,ZNF354B
RNA polymerase II core promoter proximal region sequence-specific DNA binding CEBPA,TBP,SMAD2,ZNF257,MYC,TBX3,SMAD4,JUNBB,CTCF,HOXA7
DNA binding AHR1A,EGR4,FOXO3,LRRFIP1,FOXB1A,ZBTB7A,HIST1H2B5,HOMEZ,POLR2C,GATA4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TRP63,ZFP639,MIXL1,FOXJ1,CAMTA2,SOX9,PGR,ETV2,EBF2,TFAP2E
protein domain specific binding ARR3,THRA,WNT5A,DYNLL1,CEP68,POU2F2,HIST1H4N,LIN7C,YWHAQ,YWHABA
transcription factor binding APBB3,CEBPG,SUMO1,ZFPM2,TFDP1,ETS1,NAB2,JUN,NAB1,DIP2B

Interacting Protein

E2F4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F4 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F4.

RBL2;TFDP2;LIN9;RB1;E7;MYBL2;RBL1;TFDP1

Resources

Research Area

Apoptosis Transcription Factors and Regulators
G1 (Restriction) Checkpoints

References

  • Demyanenko, SV; Uzdensky, AB; et al. PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:262-270(2014).
  • Yin, D; Xie, D; et al. DLK1: increased expression in gliomas and associated with oncogenic activities. ONCOGENE 25:1852-1861(2006).

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