DVL1
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Official Full Name
dishevelled, dsh homolog 1 (Drosophila) -
Overview
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. -
Synonyms
DVL1;dishevelled, dsh homolog 1 (Drosophila);dishevelled 1 (homologous to Drosophila dsh);segment polarity protein dishevelled homolog DVL-1;Dishevelled 1;dishevelled 1 like;Dishevelled;Dishevelled dsh homolog 1;Dishevelled-1;Dishevelled1;DSH homolog 1;Dvl 1;Dvl;DVL1_HUMAN;DVL1L1;MGC54245;Segment polarity protein dishevelled homolog DVL 1;segment polarity protein dishevelled homolog DVL 1 like;Segment polarity protein dishevelled homolog DVL1
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- His&T7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DVL1-1980R | Recombinant Rat DVL1 Protein | Mammalian Cell | Rat | His |
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| DVL1-28351TH | Recombinant Human DVL1 | Wheat Germ | Human | Non | 110 amino acids |
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| DVL1-2959H | Recombinant Human DVL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DVL1-4899M | Recombinant Mouse DVL1 Protein | Mammalian Cell | Mouse | His |
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| DVL1-6766HCL | Recombinant Human DVL1 293 Cell Lysate | HEK293 | Human | Non |
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| DVL1-1638R | Recombinant Rat DVL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DVL1-1638R-B | Recombinant Rat DVL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DVL1-1682H | Recombinant Human DVL1 protein, His & T7-tagged | E.coli | Human | His&T7 | Arg150~Lys285 |
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| Dvl1-1683M | Recombinant Mouse Dvl1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Arg150~Ser332 |
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| DVL1-2011H | Recombinant Human DVL1 Protein (Arg150-Lys285), N-His tagged | E.coli | Human | His | Arg150-Lys285 |
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| DVL1-2574M | Recombinant Mouse DVL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DVL1-2574M-B | Recombinant Mouse DVL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DVL1-4135HF | Recombinant Full Length Human DVL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 444 amino acids |
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Involved Pathway
DVL1 involved in several pathways and played different roles in them. We selected most pathways DVL1 participated on our site, such as Adipogenesis,Basal cell carcinoma,Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of DVL | DVL2,KLHL12,DACT1,HECW1,DVL3,HECW1B |
| DNA damage response (only ATM dependent) | MLKL,DVL2,DVL3,BIK |
| HTLV-I infection | MRAS,HLA-DRA,SRF,WNT2B,WNT8B,HLA-DRB5,NFKBIA,VAC14,TSPO,H2-AB1 |
| Beta-catenin independent WNT signaling | PRICKLE1B,AGO2,MOV10,RYK,CLTB,GNB5,PRICKLE1,AP2M1,DVL3,ROR1 |
| Adipogenesis | STIL,MEF2AA,CFD,RETN,KLF5,CREB1,FOXC2,NDN,CEBPB,CEBPA |
| Basal cell carcinoma | WNT8A,FZD8,WNT5B,APC,TRP53,APC2,WNT7B,FZD10,WNT9A,DVL2 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | DVL3,WNT8-2,DVL2,CSNK1G2 |
| Canonical Wnt signaling pathway | CSNK1A1,DVL2,CSNK1E,KLHL12,CSNK1D,DVL3 |
Protein Function
DVL1 has several biochemical functions, for example, Rac GTPase binding,enzyme binding,frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL1 itself. We selected most functions DVL1 had, and list some proteins which have the same functions with DVL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | SDCBP,WNT2B,LRP6,DVL1B,WNT5A,WNT7B,WNT3A,WNT8B,FZD1,WNT4A |
| identical protein binding | LTBR,UBE4A,PRPF3,MRFAP1L1,TPRGL,APIP,ALDOA,CLDN11,PLN,TP63 |
| Rac GTPase binding | SRGAP3,HACE1,SRGAP2A,ARHGAP4,ARHGEF2,PAK4,RAB7,FLNA,NOXA1,RCC2 |
| protein kinase binding | CRY1,HDAC7,TPX2,AKAP5,GSTP2,PTPRJ,SKAP1,E2F1,CDC42,GSK3B |
| protein binding | ERG,SCEL,SLC25A6,RAB34,PRKAB2,FANCB,ZFYVE28,ACACB,STX16,TH |
| molecular_function | GM4179,SHANK2-AS3,GM4305,BCL7BB,LHFPL5B,PALM1A,KHNYN,SPON2B,FBXO36A,FBXO43 |
| enzyme binding | RPS2,PHB,HDAC6,MDM2,GOT2,BACE1,APBA3,HSPA2,A2M,CBX3 |
Interacting Protein
DVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL1.
Axin1;CSNK1E;DVL3
DVL1 Related Signal Pathway
Resources
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References
- Huang, MY; Yen, LC; et al. Significant Overexpression of DVL1 in Taiwanese Colorectal Cancer Patients with Liver Metastasis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14:20492-20507(2013).
- Lee, YN; Gao, Y; et al. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1,-2, and-3. CELLULAR SIGNALLING 20:443-452(2008).
