DRD4
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Official Full Name
dopamine receptor D4 -
Overview
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens -
Synonyms
DRD4;D(4) dopamine receptor;OTTHUMP00000164435;dopamine D4 receptor;D(2C) dopamine receptor;seven transmembrane helix receptor;dopamine receptor D4;D4DR
Recombinant Proteins
- Rat
- Chicken
- Mouse
- Human
- Mustela putorius furo (European domestic ferret) (Mustela furo)
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Flag
- Avi
- Fc
Involved Pathway
DRD4 involved in several pathways and played different roles in them. We selected most pathways DRD4 participated on our site, such as Amine ligand-binding receptors,Class A/1 (Rhodopsin-like receptors),Dopamine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | ADORA2B,CHRM5,OPN1MW,NPFFR2,GPR4,PROK1,TAS2R16,EMR1,OPN4,NTS |
| Dopamine receptors | DRD3,DRD1,DRD2,DRD5 |
| Dopaminergic synapse | GSK3A,PPP3CC,CLOCK,PRKCA,GNG4,DDC,CALM4,CALM1,KIF5A,PPP2R5E |
| GPCR downstream signaling | DCLRE1B,GPR55,ARHGEF18,ARHGEF1B,ARHGEF17,CRHB,GAL,CCL35.2,ANXA1A,GPR18 |
| Class A/1 (Rhodopsin-like receptors) | OPN4B,GPR77,XK,EDN1,CGA,GPR55,PYYA,S1PR1,DRD3,ADORA3 |
| G alpha (i) signalling events | LPAR5A,CCL35.1,CHRM2,OPN1LW,CNR2,APLNR,OPN1SW,RLN3,RGS4,AGT |
| GPCRs, Class A Rhodopsin-like | GPR4,OPN4,ADORA3,GPR1,CNR2,GPR32,OR3A4P,CCR8,GPR18,SSTR2 |
| Amine ligand-binding receptors | HRH3,ADRB2,DRD5,DRD1,CHRM3,CHRM5,ADRa1A,ADRB3,CHRM2,TAAR1 |
Protein Function
DRD4 has several biochemical functions, for example, G-protein coupled amine receptor activity,SH3 domain binding,dopamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD4 itself. We selected most functions DRD4 had, and list some proteins which have the same functions with DRD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dopamine neurotransmitter receptor activity, coupled via Gi/Go | DRD4-RS,DRD4A,DRD2,DRD2L,DRD2A,DRD3,DRD2B,DRD4B |
| dopamine binding | DRD2L,SLC6A3,DRD5,DRD2B,DRD1,DRD2,DRD1B,TH,DRD2A,DRD1A |
| SH3 domain binding | CTTNBP2,ELMO2,LRP2,SIRPA,SH3BP2,PDE4D,SH3BP5B,MYPN,PLSCR3,AFAP1L2 |
| G-protein coupled amine receptor activity | TAAR9,DRD1,GPR161,DRD4A,TAAR6,TAAR7F,DRD3,TAAR13C,TAAR4,DRD1A |
| identical protein binding | RB1,TTC32,GAPDH,SLIT2,MIEF1,AGXT2L2,DVL1,TPRG1L,CLDN8,GSTM3 |
| drug binding | P2RX2,FOLR1,PDE10A,CHRM3,CHRNA3,SFRP1,MT3,GSTP2,GABRA1,RARB |
| protein binding | HNRPDL,RPH3A,ATP4B,CPNE7,ATP6V0D1,RINT1,DDX20,HINT2,TFF3,E4F1 |
| potassium channel regulator activity | SUMO1,ANK2,KCNIP3,KCNMB1,KCNAB2,KCNE2,AMIGO1,DLG1,SGK2,SGK2B |
| dopamine neurotransmitter receptor activity | DRD4-RS,DRD1A,DRD4A,DRD7,DRD5,DRD2L,DRD1,DRD1B,DRD2B,DRD2A |
Interacting Protein
DRD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD4.
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