DPM3
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Official Full Name
dolichyl-phosphate mannosyltransferase polypeptide 3 -
Overview
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. -
Synonyms
DPM3;dolichyl-phosphate mannosyltransferase polypeptide 3;dolichol-phosphate mannosyltransferase subunit 3;MGC34275;MGC125904;MGC125905;prostin 1;prostin-1;MPD synthase subunit 3;DPM synthase complex subunit 3;mannose-P-dolichol synthase subunit
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Pongo Abelii
- Bovine
- Schizosaccharomyces pombe
- Mus musculus
- Dictyostelium Discoideum
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DPM3 involved in several pathways and played different roles in them. We selected most pathways DPM3 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| N-Glycan biosynthesis | FUT8A,STT3A,MOGS,MAN2A2,ALG13,ALG1,MGAT3,MGAT1A,RABGNT1,ST6GAL2 |
| Metabolic pathways | GCDHB,PLCH2,ENO1A,APRT,CYP11B1,AGMAT,PLA2G4C,COX8C,PDXKB,CYP2U1 |
Protein Function
DPM3 has several biochemical functions, for example, contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPM3 itself. We selected most functions DPM3 had, and list some proteins which have the same functions with DPM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ELMOD3,TDRKH,MAD2L1BP,ITGA7,GPRC5A,SNX32,MUTYH,FHL1,CNOT8,MS4A12 |
| contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity | DPM2 |
Interacting Protein
DPM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPM3.
DPM1;Dpm2;DPM2;LRRK2
Resources
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References
- Yang, AC; Ng, BG; et al. Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy. MOLECULAR GENETICS AND METABOLISM 110:345-351(2013).
- Barone, R; Aiello, C; et al. DPM2-CDG: A muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy. ANNALS OF NEUROLOGY 72:550-558(2012).
