DOK6
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Official Full Name
docking protein 6 -
Overview
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM;164761) signaling cascade (Crowder et al., 2004 (PubMed 15286081)). -
Synonyms
DOK6;docking protein 6;docking protein 5 like , DOK5L;HsT3226;MGC20785;downstream of tyrosine kinase 6;DOK5L
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
DOK6 involved in several pathways and played different roles in them. We selected most pathways DOK6 participated on our site, such as Signaling events regulated by Ret tyrosine kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events regulated by Ret tyrosine kinase | PDLIM7,GFRA1,DOK4,GDNF,DOK5 |
Protein Function
DOK6 has several biochemical functions, for example, insulin receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK6 itself. We selected most functions DOK6 had, and list some proteins which have the same functions with DOK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor binding | PTPN11,INSL3,FRS2B,DOK7,ENPP1,INS2,IGF1R,IRS1,PDPK1,DOK4 |
| protein binding | HNRNPD,NR2F1,STOM,SREBF1,DYRK1B,FLOT2,TYRO3,ALDH18A1,CCDC108,TUBGCP4 |
Interacting Protein
DOK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK6.
C1orf94;RBPMS;EGFR;ERBB2;ESR2
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References
- Lapelosa, M; Patapoff, TW; et al. Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies. JOURNAL OF PHYSICAL CHEMISTRY B 118:13132-13141(2014).
- Al Olaby, RR; Cocquerel, L; et al. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein. PLOS ONE 9:-(2014).
