DOCK6
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Official Full Name
DOCK6 dedicator of cytokinesis 6 [ Homo sapiens ] -
Overview
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. -
Synonyms
dedicator of cytokinesis 6;Ensembl:ENSRNOG00000010652;dedicator of cytokinesis protein 6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK6-12121H | Recombinant Human DOCK6, His-tagged | E.coli | Human | His | 1699-2041a.a. | |
| Dock6-1369M | Recombinant Mouse Dock6 Protein, His-tagged | E.coli | Mouse | His | Phe1915-Leu2080 |
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Involved Pathway
DOCK6 involved in several pathways and played different roles in them. We selected most pathways DOCK6 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | MAFGA,OSTN,KIF4,PHF21A,KIF22,AKAP1B,GATA1A,ZFPM1,EHD1,KIF9 |
| Regulation of CDC42 activity | DNMBP,DOCK10,ARHGAP17,ITSN2,BCAR3,ARHGAP1,ARHGEF25,SPATA13,RALBP1,DOCK9 |
| Hemostasis | KIF26A,EHD1,MGC173646,TRPC3,CD9A,ZFPM1,MMRN1,AKAP1B,IRF2A,SH2B3 |
| Regulation of RAC1 activity | RAP1GDS1,SPATA13,PREX2,CHN2,CHN1,ARHGEF25,EPS8,ABR,RALBP1,DEF6 |
Protein Function
DOCK6 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK6 itself. We selected most functions DOCK6 had, and list some proteins which have the same functions with DOCK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | ITSN2A,KNDC1,FGD1,ITSN1,ARHGEF11,RANGRF,ARHGEF39,ARHGEF7,RAPGEF4,ARHGEF7A |
Interacting Protein
DOCK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK6.
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