DHX33
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Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 33 -
Overview
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. -
Synonyms
DHX33;DEAH (Asp-Glu-Ala-His) box polypeptide 33;DDX33, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 33;putative ATP-dependent RNA helicase DHX33;DKFZp762F2011;FLJ21972;DDX33;DEAD box polypeptide 33;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 33;DEAH (Asp Glu Ala His) box polypeptide 33;DEAH box protein 33;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DHX33-2610H | Recombinant Human DHX33 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DHX33-5850Z | Recombinant Zebrafish DHX33 | Mammalian Cell | Zebrafish | His |
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| DHX33-2553HF | Recombinant Full Length Human DHX33 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 707 amino acids |
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| DHX33-2572H | Recombinant Human DHX33 Protein (1-450 aa), His-tagged | E.coli | Human | His | 1-450 aa |
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| DHX33-564H | Recombinant Human DHX33 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-707a.a. |
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| Dhx33-8544M | Recombinant Mouse Dhx33 protein, His-tagged | E.coli | Mouse | His | 1-698a.a. |
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Involved Pathway
DHX33 involved in several pathways and played different roles in them. We selected most pathways DHX33 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DHX33 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX33 itself. We selected most functions DHX33 had, and list some proteins which have the same functions with DHX33. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| helicase activity | ATRX,PEO1,MOV10B.2,UPF1,NAV2,DICER1,PIF1,EP400,DHX36,MCM9 |
| nucleotide binding | PTBP1A,MAPK8B,RAB1,TUBA1L,RRP7A,NT5C1A,PABPN1,ACVR1L,ARL4CA,RBMS1 |
| hydrolase activity | DNASE1L3L,REN2,ENTPD2A.1,PPM1DB,METAP2B,ATP2B2,PTPRJA,DUSP13A,ACP5A,SPO11 |
| ATP-dependent RNA helicase activity | DDX39B,DDX23,DDX10,DDX51,DHX9,SKIV2L,G3BP1,DDX55,DDX25,DHX16 |
| poly(A) RNA binding | DHX29,NSUN5,UBA1,RTN4,RPL4,EIF1,CALR,DIAPH1,U2AF2,LARP4B |
| ATP binding | MYO1H,ABCA1B,ATP2A2,SBK3,P2RX4B,WEE1,SUCLG1,VARS,AK9,CNTN1B |
Interacting Protein
DHX33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX33 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX33.
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References
- Weng, LY; Mitoma, H; et al. The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA-Induced NLRP3 Inflammasome Activation. JOURNAL OF IMMUNOLOGY 193:3676-3682(2014).
- Liu, Y; Lu, N; et al. The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells. CELLULAR & MOLECULAR IMMUNOLOGY 11:49-57(2014).
