DHRS3
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Official Full Name
dehydrogenase/reductase (SDR family) member 3 -
Overview
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of;substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 (PubMed 10800688)). -
Synonyms
DHRS3;dehydrogenase/reductase (SDR family) member 3;short-chain dehydrogenase/reductase 3;RDH17;retSDR1;Rsdr1;SDR1;SDR16C1;short chain dehydrogenase/reductase family 16C;member 1;DD83.1;DHRS3_HUMAN;EC 1.1.1.300;MGC125166;Retinal short chain dehydrogenase/reductase 1;Retinal short-chain dehydrogenase/reductase 1;SDR family, member 3;Short-chain dehydrogenase/reductase family, member 3;OTTHUMP00000001866;short-chain dehydrogenase/reductase 1;short chain dehydrogenase/reductase family 16C, member 1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Bovine
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DHRS3 involved in several pathways and played different roles in them. We selected most pathways DHRS3 participated on our site, such as Metabolic pathways,RA biosynthesis pathway,Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Retinoic Acid | RDH13,RDH10,RARG,RDH14,PDK3,CRABP1B,DHRS4,ALDH8A1,CRABP1A,CRABP2B |
| The retinoid cycle in cones (daylight vision) | RBP3,DHRS3A,IRBP,OPN1SW1,RLBP1A,RLBP1,OPN1LW2,RLBP1B,OPN1LW1 |
| Retinol metabolism | DGAT1,AOX1,RETSAT,CYP3A41A,Aldh1a7,DHRS9,CYP3A41B,CYP2C18,RDH8,CYP3A7 |
| Visual phototransduction | PPEF1,RLBP1,BCO2A,STRA6,IRBP,GRK7,RGS9BP,BCO2L,BCO2,METAP2B |
| Vitamin A and carotenoid metabolism | BCO2,RDH12,CRABP1,RARG,CRABP2,RDH10,RBP7 |
| Metabolic pathways | AK2,QPRT,POLE,GLUD1B,DEGS1,ITPA,MUT,CYP11C1,PET112L,NT5C2A |
| RA biosynthesis pathway | RDH14A,AKR1C21,ADH8A,CRABP1B,DHRS9,DHRS3A,RDH7,RDH14B,CRABP1,RDH10 |
| Signal Transduction | RAMP2,HEBP1,ARHGAP8,STARD8,OXER1,FMNL3,TLE3B,WDR19,TAS2R16,RNF41 |
Protein Function
DHRS3 has several biochemical functions, for example, NADP-retinol dehydrogenase activity,electron carrier activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS3 itself. We selected most functions DHRS3 had, and list some proteins which have the same functions with DHRS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | ACAD9,COX11,NDUFS6,AKR1B1,ACADL,NOX4,PTGES2,XDH,IVD,COX7A1 |
| NADP-retinol dehydrogenase activity | RDH11,RDH8,RDH10B,RDH10,RDH10A |
| retinol dehydrogenase activity | RDH10,SDR16C5,ADH1,DHRS9,AKR1C3,SDR9C7,RDH5,RDH11,RDH1,DHRS7C |
| nucleotide binding | U2AF2,INSRB,ATP1A1A.2,RBM12,HELZ,PTK2AB,PDXK,GMPPAA,MTIF2,ARL5C |
Interacting Protein
DHRS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHRS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHRS3.
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References
- Adams, MK; Belyaeva, OV; et al. The Retinaldehyde Reductase Activity of DHRS3 Is Reciprocally Activated by Retinol Dehydrogenase 10 to Control Retinoid Homeostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:14868-14880(2014).
- Moise, A; Billings, S; et al. Ablation of DHRS3 is associated with alterations in retinoic acid metabolism and signaling and with defects in developmental programming in mice. FASEB JOURNAL 28:-(2014).
