DGKD
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Official Full Name
diacylglycerol kinase, delta 130kDa -
Overview
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
DGKD;diacylglycerol kinase, delta 130kDa;diacylglycerol kinase, delta (130kD);diacylglycerol kinase delta;DGKdelta;diglyceride kinase;KIAA0145;DGK-delta;DAG kinase delta;diglyceride kinase delta;dgkd-2;FLJ26930
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DGKD-26772TH | Recombinant Human DGKD, His-tagged | E.coli | Human | His | 928-1170 a.a. |
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| DGKD-1334H | Recombinant Human DGKD Protein, His-tagged | E.coli | Human | His | Pro672-Val885 |
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| Dgkd-2536M | Recombinant Mouse Dgkd Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| DGKD-3400H | Recombinant Human DGKD Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
DGKD involved in several pathways and played different roles in them. We selected most pathways DGKD participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | GRB2,PPAP2A,PDPK1,FOS,PDGFB,WASF1,MAP2K1,DGKE,EGF,PPAP2B |
| Phospholipase D signaling pathway | INS,PDGFRA,AGPAT5,SOS1,GRM3,GRM4,INS2,MTOR,CYTH1,PRKCA |
| Glycerophospholipid metabolism | PLD1,PLD2,PLA2G3,LCAT,AGPAT3,PLA2G2A,GPD2,CRLS1,AGPAT1,CDS1 |
| Metabolic pathways | GAL3ST1,POLR2L,FAM213B,ADH1B,NDUFA5,MGAT1B,OGDHA,GALNT18A,UGT8A,ATP6V0B |
| Glycerolipid metabolism | CEL.1,AKR1B1L,AGPAT4,MBOAT2B,DGKZ,glpK,ALDH7A1,LPIN3,GPAT2,PNPLA2 |
| Phosphatidylinositol signaling system | ITPKC,PIP5K1BB,CALM,MTMR1A,MTMR4,PLCE1,PIK3R3A,PLCZ1,INPP5D,PIK3R2 |
Protein Function
DGKD has several biochemical functions, for example, ATP binding,diacylglycerol kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKD itself. We selected most functions DGKD had, and list some proteins which have the same functions with DGKD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMKK1,MCMDC2,ATP7B,MAP3K3,PDPK1A,TTLL10,DHX33,CHUK,CDK11A,CHD6 |
| metal ion binding | PDE6A,ZFP609,KAT6A,HAND2,FXC1,DAK,SAP30,SCRT1B,GFI1AA,RPE |
| diacylglycerol kinase activity | DGKA,DGKG,AGK,DGKB,DGKE,TAE1,DGKZ,DGKQ,DGKAA |
Interacting Protein
DGKD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKD here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKD.
DYSF;MYH13;HAX1;q74yg8_yerpe;TNFRSF14;IGSF21;Srek1
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References
- Carracedo, S; Braun, U; et al. Expression pattern of protein kinase C delta during mouse embryogenesis. BMC DEVELOPMENTAL BIOLOGY 13:-(2013).
- Toriumi, K; Horikoshi, Y; et al. Carbon tetrachloride-induced hepatic injury through formation of oxidized diacylglycerol and activation of the PKC/NF-kappa B pathway. LABORATORY INVESTIGATION 93:218-229(2013).
