DENND1A
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Official Full Name
DENN/MADD domain containing 1A -
Overview
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members;of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early;endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024).;Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed;20154091)). -
Synonyms
DENND1A;DENN/MADD domain containing 1A;KIAA1608;DENN domain-containing protein 1A;FAM31A;FLJ21129;Connecdenn;FLJ38464;OTTHUMP00000022090;Protein FAM31A;RP11 230L22.3;connecdenn 1;RP11-230L22.3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His&SUMO
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DENND1A-1186H | Recombinant Human DENND1A Protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-559 a.a. |
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| DENND1A-2532H | Recombinant Human DENND1A Protein, GST-tagged | Wheat Germ | Human | GST |
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| DENND1A-4505M | Recombinant Mouse DENND1A Protein | Mammalian Cell | Mouse | His |
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| DENND1A-6978HCL | Recombinant Human DENND1A 293 Cell Lysate | HEK293 | Human | Non |
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| DENND1A-2324M | Recombinant Mouse DENND1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DENND1A-2324M-B | Recombinant Mouse DENND1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DENND1A-2459HF | Recombinant Full Length Human DENND1A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 559 amino acids |
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Involved Pathway
DENND1A involved in several pathways and played different roles in them. We selected most pathways DENND1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DENND1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DENND1A has several biochemical functions, for example, Rab guanyl-nucleotide exchange factor activity,SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DENND1A itself. We selected most functions DENND1A had, and list some proteins which have the same functions with DENND1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | MVB12A,CYBA,ABI2,QKI2,VASP,PTTG2,DTX1,MAPT,DOCK4,INPPL1 |
| Rab guanyl-nucleotide exchange factor activity | DENND5A,DENND1B,DCTD,ST5,DENND2D,SBF1,TRAPPC1,TRAPPC4,RIN3,DENND5B |
Interacting Protein
DENND1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DENND1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DENND1A.
Sec24c;GAK;CLTB;YWHAB;ANAPC15;CLTC;PICALM;ATL2;Tmod3;GTSE1;LIMA1;Myo1c
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